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Last updated on April 16, 2014 at 7:25 EDT

Latest Reprogramming Stories

2009-10-18 12:32:54

Development of 2-week method for generating human induced-pluripotent stem cells with 200-fold increase in yield Fate Therapeutics, Inc. announced today the generation of human induced-pluripotent stem cells (iPSCs) using a combination of small molecules that significantly improves the speed and efficiency of reprogramming. The discoveries, which were made by Sheng Ding, Ph.D. under a research collaboration between Fate Therapeutics and The Scripps Research Institute (TSRI), represent a more...

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2009-08-30 12:44:21

A team of Michigan State University researchers has developed a new, more efficient way of cloning zebra fish, a breakthrough that could have implications for human health research. The work of the MSU researchers, detailed in the recent issue of the journal Nature Methods, is important because zebra fish, small striped fish common to many aquariums, are quickly becoming the animal of choice for many researchers. "After the mouse, it is the most commonly used vertebrate in genetic studies,"...

2009-07-23 11:36:17

In a paper publishing online July 23 in Cell Stem Cell, a Cell Press journal, Dr. Shaorong Gao and colleagues from the National Institute of Biological Sciences in Beijing, China, report an important advance in the characterization of reprogrammed induced pluripotent stem cells, or iPSCs.Scientists working with iPSCs have been eager to find out if these cells are fully pluripotent, as this would tell us to what extent they have in fact been truly reprogrammed and resemble normal embryonic...

2009-07-08 14:08:52

Scientists have identified a gene that is essential for embryonic stem cells to maintain their all-purpose, pluripotent state. Exploiting the finding may lead to a greater understanding of how cells acquire their specialized states and provide a strategy to efficiently reprogram mature cells back into the pluripotent state, an elusive step in stem cell research but one crucial to a range of potential clinical treatments.The research was led by University of California, San Francisco...

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2009-07-07 16:35:00

Kinarm Ko and Hans Schöler's team at the Max Planck Institute for Molecular Biomedicine in Mnster have succeeded for the first time in culturing a clearly defined cell type from the testis of adult mice and converting these cells into pluripotent stem cells without introduced genes, viruses or reprogramming proteins. These stem cells have the capacity to generate all types of body tissue. The culture conditions alone were the crucial factor behind the success of the reprogramming...

2009-06-12 09:28:50

Three female mice have been cloned until now. The first mouse was born on 12 May, the second is now 10 days old and the third is only two days old. Scientists are studying how to improve the efficiency of the cloning process Universitat Autònoma de Barcelona (UAB) researchers are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June. By means of nuclear transfer techniques,...

2009-05-18 18:54:30

Inhalation of some particulates can cause some genes to become reprogrammed, affecting the development and outcome of cancers, Italian researchers said. Dr. Andrea Baccarelli of the University of Milan enrolled 63 healthy subjects who worked in a foundry near Milan. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor...

2009-05-18 09:21:56

A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary foundation of genomic imprinting exists in lower vertebrates and genomic imprinting should not be considered as a unique evolutionary event of mammals. The study is reported in volume 54 (Issue 8, April, 2009) of Chinese Science...

2009-05-18 07:59:46

Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego."Recently, changes in gene programming due to a...

2009-03-25 08:23:02

San Antonio and Honolulu researchers make important discoveries about point mutation rates in cloned mouse fetusesSan Antonio "¦ Germ cells, the cells which give rise to a mammal's sperm or eggs, exhibit a five to ten-fold lower rate of spontaneous point mutations than adult somatic cells, which give rise to the body's remaining cell types, tissues and organs. Despite their comparatively higher mutation rates, however, adult somatic cells are used as the donor cells in a cloning...