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Latest Resistin Stories

2009-12-15 14:19:32

The chance discovery of a genetic mutation that makes mice enormously fat but protects them from diabetes has given researchers at Boston University School of Medicine, USA, new insights into the cellular mechanisms that link obesity to Type 2 diabetes. Dr Gerald Denis and his colleagues report their findings in the current issue of The Biochemical Journal. The researchers were studying the gene, called Brd2, which had not previously been linked to body energy balance. While complete absence...

2009-09-07 08:26:35

Chronic inflammation within fat tissue is now recognized as a contributor to the many negative consequences that come with obesity -- from diabetes to cardiovascular disease, according to Yuichi Oike of Kumamoto University in Japan. Researchers hope a new discovery will point to a targeted therapy designed to limit the impact of the obesity epidemic. The new culprit Oike's team identified is a fat-derived protein called angiopoietin-like protein 2 (Angptl2). In mice, Angptl2 levels are...

2009-08-26 10:06:56

An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC. Their findings were published earlier this month in the online version of Diabetes, one of the journals of the American Diabetes Association.Signs of low-grade systemic inflammation are not uncommon among people who have the pre-diabetic condition known as...

2009-07-07 16:10:00

Obesity very often leads to insulin resistance, and now researchers reporting in the July 8 issue of Cell Metabolism, a Cell Press publication, have uncovered another factor behind that ill consequence. The newly discovered culprit"”a protein known as pigment epithelium-derived factor (PEDF for short)"”is secreted by fat cells. They also report evidence to suggest that specifically blocking that protein's action may reverse some of the health complications that come with...

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2008-11-13 09:40:39

A new biomarker may help identify people at greatest risk for heart failure. According to researchers who discovered the marker known as resisten, the risk of developing heart failure rose 38 percent for every 10 nanograms per milliliter increase in blood levels. The investigators aren't really sure how resistin ups the risk, but they note recent mouse studies linked the marker to a decline in the ability of heart muscles to contract. "This is one of the strongest predictors of new-onset...

2008-09-26 12:00:35

Hollis-Eden Pharmaceuticals, a development-stage pharmaceutical company, has reported additional positive interim data from its on-going Phase I/II clinical trial with its investigational oral drug candidate Triolex in obese insulin resistant subjects. The additional data showed that Triolex is safe and well tolerated to date, and that it significantly improved insulin sensitivity and lowered fasting blood glucose and insulin levels in obese insulin resistant subjects treated orally with...

2008-08-29 21:00:13

The systemic inflammation associated with obesity has been ruled out as a link to asthma, New Zealand researchers said. "We were disappointed not to find a 'smoking gun' that would explain the common association between obesity and asthma," lead researcher Dr. D. Robin Taylor of the University of Otago in New Zealand. "We hypothesized that the low-grade systemic inflammation present in obesity would augment the inflammation of asthma -- a synergistic effect -- or alternatively, that the...

2008-08-09 03:00:09

By Kanaka-Gantenbein, Christina Margeli, Alexandra; Pervanidou, Panagiota; Sakka, Sophia; Mastorakos, George; Chrousos, George P; Papassotiriou, Ioannis BACKGROUND: Although there is much evidence regarding the physiologic and pathogenic roles of the newly described adipokines retinol-binding protein 4 (RBP4) and lipocalin-2 as potential promoters of insulin resistance in obese adults, relatively little information exists regarding their roles in obese children. METHODS: We investigated the...

2005-07-20 16:20:00

BOSTON -- A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes. The findings appear in the July 21, 2005, issue of the journal Nature. According to senior author Barbara B. Kahn, MD, Chief of the Division of...

2004-11-26 03:00:09

For the public, obesity is largely a cosmetic issue. For the doctor, it underlies disturbances of lipid and glucose metabolism that are posing one of the greatest threats to health the world has known. Diabetes, cardiovascular disease, cancers and anovulation are the principal manifestations. Insulin resistance, consequent upon obesity, causes them and metabolic syndrome is the term used to describe them. Metabolic syndrome results from the maladaptation to overnutrition of genes selected to...