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Latest Retrovirus Stories

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2012-03-12 09:14:46

The human immunodeficiency virus (HIV) is a complex creature that researchers have been working on getting the upper hand on for 30 years. It appears, however, that scientists are finally making real progress on several fronts in the search for a cure for HIV infections. Early human trials of vaccines designed to prevent or treat infection with the difficult to target virus have proved disappointing. HIV is a “provirus” that is integrated into the DNA of a host cell, where it...

2012-02-23 18:00:04

The many short pieces of mobile DNA that exist in the genome can contribute to significant biological differences between lineages of mice, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James). The movable pieces of DNA are called transposons or "jumping genes" because they can move from one chromosomal location to another. Unlike viruses,...

2011-12-22 06:56:25

Hundreds of connections between viral and human proteins identified in UCSF-led study -- work that may reveal new drug targets In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by researchers at the University of California, San Francisco has mapped every apparent physical interaction the virus makes with components of the human cells it infects–work that may reveal new ways to design future HIV/AIDS drugs. Explored this...

2011-12-13 06:35:15

(Ivanhoe Newswire) — Scientists have discovered the ℠key´ that HIV uses to enter our cells´ nuclei and halt our immune system, eventually causing AIDS. These findings provide a potential new target for anti-AIDS drugs that could be more effective against drug-resistant strains of the virus. According to the World Health Organization, 33.3 million people were living with HIV in 2009, of which 2.6 million were newly infected. Without treatment, the virus causes...

2011-10-07 11:02:55

A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction. The findings are published in the Open Access journal PLoS Pathogens on October 6th. TLR7 is...

Gamers Crack AIDS Enzyme That Had Stumped Scientists
2011-09-19 04:51:58

  Video game players have successfully pieced together the structure of a retrovirus enzyme that causes an AIDS-like ailment in rhesus monkeys--an enzyme whose configuration had stumped scientists from more than a decade, according to various reports. The feat, which is the topic of a paper published online in the journal Nature Structural & Molecular Biology on Sunday, was accomplished by players on a collaborative computer title called Foldit. Launched by the University of...

2011-04-07 16:50:16

Thematic program focuses on DNA replication, recombination and repair DNA's role as the master blueprint of the cell means that even small sequence changes can have catastrophic consequences. For this reason, much of our understanding of cancer development comes from studying how cells copy DNA and repair sequence errors -- and how these processes can go wrong. Next week, a thematic program at the American Society for Biochemistry and Molecular Biology's annual meeting at the Experimental...

2011-03-25 11:47:56

The human immunodeficiency virus (HIV), the cause of AIDS, makes use of the base excision repair pathway when inserting its DNA into the host-cell genome, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center "“ Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Crippling the repair pathway prevents the virus from completing this critical step in the retrovirus's life cycle. The findings offer potential new targets...

2011-03-11 15:36:23

How host factors aid in the release of HIV particles Human Immunodeficiency Virus (HIV) "“ which causes AIDS "“ invades human immune cells and causes them to produce new copies of the virus, which can then infect new cells. A research team led by Professor Don C. Lamb (LMU Munich) and Priv.-Doz. Dr. Barbara Mller of Heidelberg University Hospital have now analyzed the involvement of particular components of the infected cell in virion release, and discovered that the enzyme VPS4A...

2011-02-25 12:57:27

Although untreated HIV infection eventually results in immunodeficiency (AIDS), a small group of people infected with the virus, called elite suppressors (0.5 percent of all HIV-infected individuals), are naturally able to control infection in the absence of antiretroviral therapy, or HAART. Elite suppressors and HIV- infected individuals treated with HAART have similar levels of virus in the blood stream. However, levels of HIV integrated into immune cells are much lower in elite suppressors...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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