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Latest Ribosome Stories

2013-06-17 09:56:18

Because of their central importance to biology, proteins have been the focus of intense research, particularly the manner in which they are produced from genetically coded templates–a process commonly known as translation. While the general mechanism of translation has been understood for some time, protein synthesis can initiate by more than one mechanism. One of the least well understood mechanisms is known as cap-independent translation. Now, John Chaput and his colleagues at...

2013-06-06 20:02:51

Structural and molecular differences between human Argonaute proteins reveal essential elements for RNA-slicing Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression. Human Argonaute-2 (hAgo2) is known as "slicer" for its unique ability among the 4 human Argonaute proteins to directly cut messenger RNA -- which carries the information coded in genomic DNA to make a...

2013-04-30 10:59:42

Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease. Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered how an enzyme co-factor can bestow specificity on a class of proteins with otherwise nonspecific biochemical activity. The protein in question helps in the assembly of ribosomes, large macromolecular machines that...

2013-01-15 10:44:38

Using an innovative approach, scientists at The Scripps Research Institute (TSRI) have determined the structure of Ltn1, a recently discovered “quality-control” protein that is found in the cells of all plants, fungi and animals. Ltn1 appears to be essential for keeping cells´ protein-making machinery working smoothly. It may also be relevant to human neurodegenerative diseases, for an Ltn1 mutation in mice leads to a motor-neuron disease resembling amyotrophic lateral...

Researchers Building Nanomachine Inspired By Ribosomes
2013-01-13 10:16:51

redOrbit Staff & Wire Reports — Your Universe Online Researchers at the University of Manchester have developed a machine that can effectively mimic the process by which the ribosome translates genetic code to build protein in the cells of our bodies. The nanomachine, which is only a few millionths of a millimeter long, was constructed by professor David Leigh of the university´s School of Chemistry, and in a statement, the institute called it “the most advanced...

2012-11-07 11:49:14

Scientists have adopted a novel laboratory approach for determining the effect of genetic variation on the efficiency of the biological process that translates a gene's DNA sequence into a protein, such as hemoglobin, according to a presentation, Nov. 6, at the American Society of Human Genetics 2012 meeting in San Francisco. In the 0.1% of the DNA that differs between any two individuals, scientists search for the biological mechanisms underlying human genetic differences, including...

2012-07-20 01:50:16

New research has shown that a protein does something that scientists once thought impossible: It unfolds itself and refolds into a completely new shape. This protein, called RfaH, activates genes that allow bacterial cells to launch a successful attack on their host, causing disease. The researchers determined that RfaH starts out in its alpha form, composed of two spiral shapes. Later, in its beta form, it resembles spokes on a wheel and is called a barrel. When RfaH refolds, it...

2012-07-05 23:58:43

The findings have implications for the development of new anti-cancer drugs Scientists from the Florida campus of The Scripps Research Institute have identified a series of intricate biochemical steps that lead to the successful production of proteins, the basic working units of any cell. The study, which appears in the July 6, 2012 edition of the journal Cell, sheds light on the assembly of a structure called the ribosome, a large and complex protein-producing machine inside all living...

2012-06-11 10:24:04

Apramycin, already used in animals, shows promise against drug-resistant TB and other "superbugs", without hearing loss ANN ARBOR, Mich., June 11, 2012 /PRNewswire-USNewswire/ -- The world needs new antibiotics to overcome the ever-increasing resistance of disease-causing bacteria - but it doesn't need the side effect that comes with some of the most powerful ones now available: hearing loss. Today, researchers report they have developed a new approach to designing antibiotics that kill...

2012-05-10 23:14:49

Ribonucleoprotein granules exit the nucleus via a budding mechanism akin to herpes-type viruses The movement of genetic materials, such as RNA and ribosomes, from the nucleus to the cytoplasm is a critical component in a cell's ability to make the proteins necessary for essential biological functions. Until now, it was believed the nuclear pore complex was the sole pathway between the cell nucleus and cytoplasm for these materials. New evidence published in Cell by Vivian Budnik, PhD,...