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Latest Ribosome Stories

2011-05-19 08:00:00

SAN FRANCISCO, May 19, 2011 /PRNewswire/ -- Sutro Biopharma, a biopharmaceutical company developing novel and biosuperior protein therapeutics with improved pharmaceutical properties, today announced that a study published in the July issue of Biotechnology and Bioengineering demonstrates that the company's biochemical protein synthesis technology platform enables fast and high-yield protein synthesis and scale-up with straightforward downstream purification processes. In the study, the...

2011-05-18 16:32:56

How do genes control us? This fundamental question of life still remains elusive despite decades of research. Genes are blueprints for proteins, but it is the proteins that actually carry out vital functions in the body for maintaining life. Diseases such as cancer are not only characterized by altered genes, but also by disturbed protein production. But how is protein production controlled? Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch of the Helmholtz...

2011-05-04 15:06:01

Scientists have discovered a new component of mitochondria that plays a key part in their function. The discovery, which is presented in the journal Cell Metabolism, is of potential significance to our understanding of both inherited and age-related diseases. Mitochondria are normally called the cell's power plants since they convert the energy in our food into a form that the body can use. To work properly, the mitochondria have to form new proteins, which they do in their ribosomes. A group...

2011-04-20 15:05:19

Intracellular transport mechanism dissected In a multicellular organism, different cells fulfill a range of diversified functions. Often such specialization depends on the delivery of molecular goods to distinct places within a cell. It ensures that particular functions only occur at defined cellular sites. This establishment of intracellular asymmetry in the otherwise fluid environment of the cell cytoplasm requires active transport processes. Messenger RNAs (mRNA) represent an especially...

2011-04-18 13:05:01

In two new studies, researchers provide the first detailed view of the elaborate chemical and mechanical interactions that allow the ribosome "“ the cell's protein-building machinery "“ to insert a growing protein into the cellular membrane. The first study, in Nature Structural and Molecular Biology, gives an atom-by-atom snapshot of a pivotal stage in the insertion process: the moment just after the ribosome docks to a channel in the membrane and the newly forming protein winds...

2011-03-30 17:13:54

Researchers have built a computer model of the crowded interior of a bacterial cell that "“ in a test of its response to sugar in its environment "“ accurately simulates the behavior of living cells. The new "in silico cells" are the result of a collaboration between experimental scientists at the Max Planck Institute of Biology in Germany and theoretical scientists at the University of Illinois using the newest GPU (graphics processing unit) computing technology. Their study...

2011-02-23 13:16:32

Researchers at the University of Illinois at Chicago have discovered a signaling mechanism in the bacterial ribosome that detects proteins that activate genes for antibiotic resistance. "The ribosome is one of the most complex molecular machines in the cell," said Alexander Mankin, UIC professor and director of the Center for Pharmaceutical Biotechnology. It is responsible for the production of all proteins in the cell, and in bacteria it is one of the major antibiotic targets. Understanding...

2010-12-23 02:18:44

Findings could point to possible new target for cancer studies, potential treatments A scientist from the Florida campus of The Scripps Research Institute has discovered a molecular switch that controls the synthesis of ribosomes. Ribosomes are the large machineries inside all living cells that produce proteins, the basic working units of any cell. These new findings offer a novel target for potential treatments for a range of diseases, including cancer. The study is published in the December...

2010-12-13 14:27:07

Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure of a ribosome-protein complex involved in carrying nascent proteins out of the cell. Their work, published online today in Nature Structural and Molecular Biology, could increase understanding of...

2010-12-06 14:05:24

Einstein College of Medicine research shows certain genes are 'clueless' Scientists at Albert Einstein College of Medicine of Yeshiva University have made an unexpected finding about the method by which certain genes are activated. Contrary to what researchers have traditionally assumed, genes that work with other genes to build protein structures do not act in a coordinated way but instead are turned on randomly. The surprising discovery, described in the December 5 online edition of Nature...