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Last updated on April 17, 2014 at 1:21 EDT

Latest Ribosome Stories

2009-11-25 15:17:34

When cells are confronted with an invading virus or bacteria or exposed to an irritating chemical, they protect themselves by going off their DNA recipe and inserting the wrong amino acid into new proteins to defend them against damage, scientists have discovered. These "regulated errors" comprise a novel non-genetic mechanism by which cells can rapidly make important proteins more resistant to attack when stressed, said Tao Pan, Professor of Biochemistry and Molecular Biology at the...

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2009-11-24 12:23:36

The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS). These protein motors play pivotal roles in gene expression and replication, and are vital to the survival of all biological cells, as well as infectious agents, such as the human papillomavirus, which has been linked to cervical...

2009-11-23 12:25:22

Two new studies reveal in unprecedented detail how the ribosome interacts with other molecules to assemble new proteins and guide them toward their destination in biological cells. The studies used molecular dynamics flexible fitting (MDFF) to examine the interaction of the ribosome with two prominent molecular partners. The first study, in Proceedings of the National Academy of Sciences, concerns the intimate signaling between the ribosome and an elongation factor (EF-Tu) that is essential...

2009-11-15 12:18:59

Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow. Just as some drugs work better together, however, other pairings are counter-productive. "The question we asked was how can it be that two drugs in combination are less effective than one of them alone," said senior author...

2009-10-30 16:40:41

Ever since the previously unknown SARS virus emerged from southern China in 2003, University of Texas Medical Branch at Galveston virologists have focused on finding the source of the pathogen's virulence "” its ability to cause disease. In the 2003 epidemic, for example, between 5 and 10 percent of those who fell sick from the SARS virus died, adding up to more than 900 fatalities worldwide. Now, UTMB researchers have uncovered what they believe could be the major factor contributing...

2009-10-15 14:41:47

Even as research on the ribosome, one of the cell's most basic machines, is recognized with a Nobel Prize, scientists continue to achieve new insights on the way ribosomes work. Ribosomes are factories inside cells where messages coming from genes are decoded and new proteins pieced together on an assembly line. For the first time, scientists have a detailed picture of the ribosome trapped together with elongation factor G (EF-G), one of the enzymes that nudges the assembly line to move...

2009-10-15 12:34:26

NSF funding in basic research yields great payoffs in scientific contributions worldwide The National Science Foundation (NSF) congratulates the 2009 Nobel laureates, particularly those who have received NSF funding over the years: Jack W. Szostak, who shared the prize in physiology or medicine; Thomas A. Steitz, who shared the prize in chemistry; and Elinor Ostrom and Oliver E. Williamson who earned the Sveriges Riksbank Prize in economic sciences in memory of Alfred Nobel 2009. "Through a...

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2009-10-07 13:35:00

Three scientists were awarded the Nobel chemistry prize Wednesday for their groundbreaking work in mapping the ribosome, which creates protein for human life. The Royal Swedish Academy of Sciences announced that Venkatraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath would receive the chemistry award for using X-ray crystallography to show what a ribosome looks like and how it functions at the atomic level. Ribosomes are responsible for the creation of proteins: oxygen-transporting...

2009-10-07 11:22:00

NEW HAVEN, Conn., Oct. 7 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc., a company focused on the discovery, development and commercialization of novel drugs for the treatment of multi-antibiotic resistant infections, today announced that Rib-X Co-Founder and Chair of the Scientific Advisory Board, Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and a Howard Hughes Medical Institute Investigator, Thomas A. Steitz, Ph.D., has been awarded the Nobel Prize in...

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2009-08-26 08:20:00

Researchers at the University of California, Berkeley, have for the first time captured elusive nanoscale movements of ribosomes at work, shedding light on how these cellular factories take in genetic instructions and amino acids to churn out proteins.Ribosomes, which number in the millions in a single human cell, have long been considered the "black boxes" in molecular biology. "We know what goes in and what comes out of ribosomes, but we're only beginning to learn about what is going on in...