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Latest Ribosome Stories

2009-12-10 11:27:58

Nature's solution to age-old chemical paradox provides clues to health and disease Even small errors made by cells during protein production can have profound disease effects, and nature has developed ways to uncover these mistakes and correct them. Though in the case of one essential protein building block"”the amino acid alanine"”nature has been extra careful, developing not one, but two checkpoints in her effort to make sure that this component is used correctly. Now,...

2009-12-02 18:53:40

Yale University researchers have found very large RNA structures within previously unstudied bacteria that appear crucial to basic biological functions such as helping viruses infect cells or allowing genes to "jump" to different parts of the chromosome. These exceptionally large RNA molecules have been discovered using DNA sequence data available within the past few years. The findings, reported in the December 3 issue of the journal Nature, suggest many other unusual RNAs remain to be found...

2009-11-25 15:17:34

When cells are confronted with an invading virus or bacteria or exposed to an irritating chemical, they protect themselves by going off their DNA recipe and inserting the wrong amino acid into new proteins to defend them against damage, scientists have discovered. These "regulated errors" comprise a novel non-genetic mechanism by which cells can rapidly make important proteins more resistant to attack when stressed, said Tao Pan, Professor of Biochemistry and Molecular Biology at the...

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2009-11-24 12:23:36

The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS). These protein motors play pivotal roles in gene expression and replication, and are vital to the survival of all biological cells, as well as infectious agents, such as the human papillomavirus, which has been linked to cervical...

2009-11-23 12:25:22

Two new studies reveal in unprecedented detail how the ribosome interacts with other molecules to assemble new proteins and guide them toward their destination in biological cells. The studies used molecular dynamics flexible fitting (MDFF) to examine the interaction of the ribosome with two prominent molecular partners. The first study, in Proceedings of the National Academy of Sciences, concerns the intimate signaling between the ribosome and an elongation factor (EF-Tu) that is essential...

2009-11-15 12:18:59

Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow. Just as some drugs work better together, however, other pairings are counter-productive. "The question we asked was how can it be that two drugs in combination are less effective than one of them alone," said senior author...

2009-10-30 16:40:41

Ever since the previously unknown SARS virus emerged from southern China in 2003, University of Texas Medical Branch at Galveston virologists have focused on finding the source of the pathogen's virulence "” its ability to cause disease. In the 2003 epidemic, for example, between 5 and 10 percent of those who fell sick from the SARS virus died, adding up to more than 900 fatalities worldwide. Now, UTMB researchers have uncovered what they believe could be the major factor contributing...

2009-10-15 14:41:47

Even as research on the ribosome, one of the cell's most basic machines, is recognized with a Nobel Prize, scientists continue to achieve new insights on the way ribosomes work. Ribosomes are factories inside cells where messages coming from genes are decoded and new proteins pieced together on an assembly line. For the first time, scientists have a detailed picture of the ribosome trapped together with elongation factor G (EF-G), one of the enzymes that nudges the assembly line to move...

2009-10-15 12:34:26

NSF funding in basic research yields great payoffs in scientific contributions worldwide The National Science Foundation (NSF) congratulates the 2009 Nobel laureates, particularly those who have received NSF funding over the years: Jack W. Szostak, who shared the prize in physiology or medicine; Thomas A. Steitz, who shared the prize in chemistry; and Elinor Ostrom and Oliver E. Williamson who earned the Sveriges Riksbank Prize in economic sciences in memory of Alfred Nobel 2009. "Through a...

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2009-10-07 13:35:00

Three scientists were awarded the Nobel chemistry prize Wednesday for their groundbreaking work in mapping the ribosome, which creates protein for human life. The Royal Swedish Academy of Sciences announced that Venkatraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath would receive the chemistry award for using X-ray crystallography to show what a ribosome looks like and how it functions at the atomic level. Ribosomes are responsible for the creation of proteins: oxygen-transporting...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.