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Latest Ribozymes Stories

2009-02-03 15:28:57

A new therapy being developed at the University of Florida could, in time, produce another weapon for the fight against herpes.The gene-targeting approach uses a specially designed RNA enzyme to inhibit strains of the herpes simplex virus. The enzyme disables a gene responsible for producing a protein involved in the maturation and release of viral particles in an infected cell. The technique appears to be effective in experiments with mice and rabbits, but further research is required before...

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2008-08-21 17:50:00

A new study of the ribosome, the cell's protein-building machinery, sheds light on the oldest branches of the evolutionary tree of life and suggests that differences in ribosomal structure between the three main branches of that tree are "molecular fossils" of the early evolution of protein synthesis. The new analysis, from researchers at the University of Illinois, reveals that key regions of the ribosome differ between bacteria and archaea, microbes that the researchers say are genetically...

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2007-03-20 08:20:00

Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new RNA molecules. Their results provide insight into what may have been the first self-replicating molecule to arise billions of years ago on the evolutionary path toward the emergence of life. In all forms of life known today, the synthesis of DNA and RNA molecules is carried out by enzymes made of...

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2006-08-23 08:59:08

Water, that molecule-of-all-trades, is famous for its roles in shaping the Earth, sustaining living creatures and serving as a universal solvent. Now, researchers at the University of Michigan and the Academy of Sciences of the Czech Republic have uncovered two previously unknown roles for water in RNA enzymes, molecules which themselves play critical roles in living cells and show promising medical applications. The researchers' findings will be published online in the Proceedings of the...

2005-07-04 18:30:00

A Howard Hughes Medical Institute investigator from Albany, New York, and an HHMI international research scholar from Buenos Aires, Argentina have combined their expertise to identify two peculiar features of the protein-making machinery of the parasite that causes Chagas disease. Their findings could help scientists develop a safe and effective drug for the disease, whose cardiac complications kill up to 30 percent of those infected. The unusual structure of the ribosome, published online...