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Last updated on April 19, 2014 at 5:20 EDT

Latest Richard I. Morimoto Stories

2013-10-30 10:43:03

The National Institutes of Health (NIH) has chosen two leading aging researchers at Albert Einstein College of Medicine of Yeshiva University to chair panels at the first symposium on "geroscience"—the study of how aging influences the onset of chronic diseases. Aging is a major risk factor for major chronic diseases including cancer, cardiovascular disease and diabetes. Understanding the biological processes that underlie aging could lead to new ways of treating or even preventing...

2012-11-30 12:24:57

OAKLAND, Calif., Nov. 30, 2012 /PRNewswire-USNewswire/ -- The Kenneth Rainin Foundation announced today its next Innovations Symposium, which will be held on Friday, July 12, 2013 at The Four Seasons Hotel Chicago. This unique one-day symposium will bring together preeminent investigators from a variety of disciplines to present their cutting-edge research on the molecular and cellular aspects of inflammatory and stress response pathways presented in the context of Inflammatory...

2012-01-23 21:51:13

A group of researchers led by the Institute of Biotechnology and Biomedicine (IBB) and Universitat Autònoma de Barcelona (UAB) have achieved to quantify with precision the effect of protein aggregation on cell aging processes using as models the Escherichia coli bacteria and the molecule which triggers Alzheimer's disease. Scientists demonstrated that the effect can be predicted before it occurs. Protein aggregation is related to several diseases, including neurodegenerative...

2012-01-06 15:19:53

Studies identify promising genes and small molecules to use against devastating diseases Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes. To do its job properly within the cell, a protein first must fold itself into the proper shape. If it...

2011-08-24 21:53:33

Evidence found for a neuronal switch to prevent neurodegenerative diseases Scientists at Northwestern University report a surprising discovery that offers a possible new route for the treatment of neurodegenerative diseases. In a study of the transparent roundworm C. elegans, they found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins. Neurodegenerative diseases,...

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2009-10-30 10:00:29

Like yoga for office drones, cells do have coping strategies for stress. Heat, lack of nutrients, oxygen radicals "“ all can wreak havoc on the delicate internal components of a cell, potentially damaging it beyond repair. Proteins called HSPs (heat shock proteins) allow cells to survive stress-induced damage. Scientists have long studied how HSPs work in order to harness their therapeutic potential. Donna George, PhD, Associate Professor of Genetics, and Julie Leu, PhD, Assistant...

2009-08-24 14:00:00

U.S. researchers say they've determined protein damage common in neurodegenerative and age-associated diseases might be treatable if detected early enough. Northwestern University medical scientists say misfolded and damaged proteins can be detected much earlier than has been thought possible, long before individuals exhibit symptoms. And if intervention occurs early enough damage could be delayed. The researchers said they studied seven different proteins of the worm C. elegans and found...

2009-02-20 10:02:32

People everywhere are feeling the stress of a worldwide recession. Our cells, too, are under continual assault from stress.Hidden from sight, our cells battle challenges such as their environment, bacteria, viruses, too much or too little oxygen, and physiological stressors. Molecular systems protect cells under assault, but those systems can break down, especially with age.To better understand how cells are protected from stress and damage, a team led by Northwestern University researchers...

2008-08-25 09:00:30

Proteostasis Therapeutics, Inc. (PTI) today announced that it has secured $45 million in a Series A financing to develop Proteostasis Regulator(TM) drugs as novel therapies to treat multiple genetic and degenerative disorders associated with protein homeostasis deficiencies. Investors included HealthCare Ventures, Fidelity Biosciences, New Enterprise Associates, Novartis Option Fund and Genzyme Ventures. "Proteostasis Therapeutics brings together innovative discoveries, leading scientists...