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Latest RNA splicing Stories

2014-08-07 16:27:47

-Results published in Science show small molecule SMN2 splicing modifiers to be effective in SMA mouse models- SOUTH PLAINFIELD, N.J., Aug. 7, 2014 /PRNewswire/ -- Today the journal Science published results of a preclinical study demonstrating that treatment with orally available RNA splicing modifiers of the SMN2 gene starting early after birth is preventing deficits in mouse models of Spinal Muscular Atrophy (SMA). Scientists from Roche Pharma Research and Early Development...

Genome Of Stress-tolerant Tomato Relative Sequenced
2014-07-30 03:56:37

By Andy Fell, UC Davis The genome of Solanum pennellii, a wild relative of the domestic tomato, has been published by an international group of researchers including the labs headed by Professors Neelima Sinha and Julin Maloof at the UC Davis Department of Plant Biology. The new genome information may help breeders produce tastier, more stress-tolerant tomatoes. The work, published July 27 in the journal Nature Genetics, was lead by Björn Usadel and colleagues at Aachen University in...

2014-04-22 10:47:36

Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function of the heart. Using mouse models, researchers at Baylor College of Medicine have now been able to categorize the alternative splicing (the process in which genes code proteins, determining their role) that takes place during these changes and what mechanisms they affect. The findings, which appear in...

Faulty Enzymes Cause Diabetic Cardiomyopathy
2013-11-07 09:18:20

redOrbit Staff & Wire Reports - Your Universe Online A family of enzymes that controls the functions of other proteins could be the possible cause of heart failure in diabetics, according to new research appearing in the Journal of Biological Chemistry. While many studies have been written on cardiovascular disease and diabetes, little is known about diabetic cardiomyopathy, a disorder of the heart muscle in diabetes patients that can lead to the heart’s inability to effectively...

Unraveling Secrets Of The Mechanism That Snips Our Genes
2013-09-27 09:50:05

Brandeis University Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing. These conditions are difficult to prevent because scientists are still grasping to understand how the splicing process works. Now, researchers from Brandeis University and the University of Massachusetts Medical School have teamed up to unravel...

2013-07-12 23:34:31

New enclosure is flexible, allows for expansion Spartanburg, SC (PRWEB) July 11, 2013 AFL Introduces Optical Splicing and Distribution Enclosure AFL is introducing the LL-580 optical splicing and distribution enclosure designed for organizing, splicing and interconnecting fibers. The enclosure addresses the need to patch, patch and splice, express cut/drop fibers and manage wavelengths (WDM or splitters) in a single enclosure. Given its flexibility, the enclosure is an ideal fit for...

2013-06-24 14:45:26

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today. Roughly 3 meters of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others. Dr Tim Mercer and Professor John...

2013-06-13 10:00:50

Microbes are living more than 500 feet beneath the seafloor in 5 million-year-old sediment, according to new findings by researchers at the University of Delaware and Woods Hole Oceanographic Institution (WHOI). Genetic material in mud from the bottom of the ocean – called the deep biosphere –revealed an ecosystem of active bacteria, fungi and other microscopic organisms at depths deeper than a skyscraper is high. The findings were published in Nature on June 12. “This...

Shining Light On Important Role Performed By Dark Matter Within Each Of Our Genes
2013-01-07 09:28:56

University of North Carolina Health Care Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or "junk DNA," within each of our genes. The new study reveals snippets of information contained in dark matter that can alter the way a gene is assembled. "These small sequences of genetic information tell the gene how to splice, either by enhancing the splicing process or...


Word of the Day
maffling
  • To stammer.
  • Present participle of maffle, to stammer.
  • A simpleton.
The word 'maffle' may come from a Dutch word meaning 'to move the jaws' or a French word meaning 'having large cheeks'.