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Latest RNA splicing Stories

2010-07-12 13:26:46

Antisense oligonucleotides delivered into spinal cords of adult and neonatal mice provide a long term rescue from disease symptoms The devastating, currently incurable motor-neuron disease spinal muscular atrophy (SMA) might soon be treated with tiny, chemically modified pieces of RNA called antisense oligonucleotides (ASOs). Scientists at Cold Spring Harbor Laboratory (CSHL) and California-based Isis Pharmaceuticals have succeeded in reversing symptoms of Type III SMA, a relatively mild form...

2010-06-09 13:53:57

A bacteria that lives in hot springs in Japan may help solve one of the mysteries of the early evolution of complex organisms, according to a study publishing next week in PLoS Biology. It may also be the key to 21st century biofuel production. Biochemists Alan Lambowitz and Georg Mohr began investigating Thermosynechococcus elongatus, a cyanobacterium that can survive at temperatures up to 150 degrees Fahrenheit, after they noticed an unusually high percentage of the bacteria's genetic...

2010-04-27 18:58:45

A rose by any other name may smell as sweet, but it would no longer be a rose. If a grass is booted out of the grass family, where does it go? Leah Morris and Dr. Melvin Duvall from Northern Illinois University recently investigated the evolution of grasses, one of the most economic and ecologically important plant families, by sequencing the chloroplast DNA of an early diverging grass genus, Anomochloa, and comparing it to the chloroplasts of other grasses. Their results are published in the...

2010-03-22 05:00:00

SAN DIEGO, March 22 /PRNewswire/ -- OFC/NFOEC 2010, Booth 1023 - OFS today announces the commercial release of its active clad alignment FITEL® S153A hand-held fusion splicer to the North American market at the industry's premier annual conference, OFC/NFOEC in San Diego, California March 21-25, 2010. "The key advantage of the FITEL S153A splicer is that it helps to achieve lower splicing loss with less user skills required as compared to a conventional fixed v-groove...

2010-03-22 11:03:29

Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template for protein production. But more than box office revenues are at stake: if the spliceosome makes a careless cut, disease likely results. Using a new approach to studying the spliceosome, a team led by University of Michigan chemistry and biophysics professor Nils Walter,...

2010-03-01 15:23:03

STANFORD, Calif. "” Like homing in to an elusive radio frequency in a busy city, human embryonic stem cells must sort through a seemingly endless number of options to settle on the specific genetic message, or station, that instructs them to become more-specialized cells in the body (Easy Listening, maybe, for skin cells, and Techno for neurons?). Now researchers at the Stanford University School of Medicine have shown that this tuning process is accomplished in part by restricting the...

2010-02-05 13:54:29

A novel finding, described today (Feb. 4) on the Science Express Web site by teams from the National Cancer Institute, The University of Texas Health Science Center at San Antonio and the University of Toronto, offers a clue as to how genes can have what you might call multiple personalities. Genes are long strings of DNA letters, but they can be cut and spliced to make different proteins, something like the word "Saskatchewan" can have its middle cut out to leave the word "Swan," its front,...

2010-01-25 07:14:49

Research on the genetic defect that causes myotonic muscular dystrophy has revealed that the mutation disrupts an array of metabolic pathways in muscle cells through its effects on two key proteins. A study published in Nature Structural & Molecular Biology shows that the loss of a single protein accounts for most of the molecular abnormalities associated with the disease, while loss of a second protein also seems to play an important role. Each of the affected proteins interacts with an...

2010-01-22 15:48:44

Understanding and overcoming "Ëœthe Warburg Effect' A team of scientists led by Professor Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory has discovered molecular factors in cancer cells that boost the production of an enzyme that helps alter the cells' glucose metabolism.  The altered metabolic state, called the Warburg effect, promotes extremely rapid cell proliferation and tumor growth. Discovered eighty years ago by Nobel Prize-winning scientist Otto Warburg, this...

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2009-12-15 08:25:00

TAU researchers unravel the mysteries of DNA packaging Imagine a huge spool of film containing thousands of sequences of random scenes. Without a talented editor, a screening would have no meaning. The RNA "spools" that make up DNA in our genes need careful editing, too. Genes are composed of meaningful sequences, called exons, separated by meaningless junk sections called introns. In order for cells to produce RNA "” the material that is required to create proteins that are vital for...


Word of the Day
toccata
  • In music, a work for a keyboard-instrument, like the pianoforte or organ, originally intended to utilize and display varieties of touch: but the term has been extended so as to include many irregular works, similar to the prelude, the fantasia, and the improvisation.
This word is Italian in origin, coming from the feminine past participle of 'toccare,' to touch.
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