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Last updated on April 21, 2014 at 1:20 EDT

Latest RNA splicing Stories

2009-12-07 20:02:13

University of Georgia scientists looking to understand the genetic mechanisms of plant defense and growth have found for the first time in plants an inverse relationship between gene duplication and alternative splicing. The finding has implications for diversity not only in plants, but in animals and humans. The research will be published online in this week's Proceedings of the National Academy of Sciences. "This inverse relationship has been previously reported in animals," said University...

2009-11-04 15:00:26

A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of a research collaboration involving Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory (CSHL) and scientists from Paratek Pharmaceuticals and Rosalind Franklin University of Medicine and Science. SMA is caused by mutations in a gene called Survival of Motor Neuron 1...

2009-08-17 09:28:08

Better tools for manipulating DNA in the laboratory may soon be possible with newly discovered deoxyribozymes (catalytic DNA) capable of cleaving single-stranded DNA, researchers at the University of Illinois say.The deoxyribozymes accomplish the DNA cleavage with the sequence-selectivity and site-selectivity required for a practical catalyst, the researchers say."Our work suggests that deoxyribozymes have significant potential as sequence-specific DNA cleavage reagents," said chemistry...

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2009-07-28 09:40:00

Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world.Ravindra Singh, associate professor in biomedical sciences at Iowa State University's College of Veterinary Medicine, would like to see Spinal Muscular Atrophy lose its high ranking and even slide off the list altogether.Most Spinal Muscular Atrophy sufferers -- more than 95 percent -- have a mutated or deleted gene called Survival Motor Neuron 1 (SMN1) that doesn't correctly do its job of creating functional...

2009-06-02 11:46:49

Emotions, popularly seated in the heart, shift with the alternative stimuli of love, hate and emotion.The developing heart requires another kind of shift. The proteins that prompt alternative splicing "“ the mechanism by which one gene can generate a host of proteins "“ must also be dynamic, said a group of researchers including those at Baylor College of Medicine in a report that appears in a recent issue of the journal Proceedings of the National Academy of Sciences.Programming...

2009-05-22 10:10:00

The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the open access journal BMC Bioinformatics shows scientists how to monitor alternative splicing activity on a genome-wide scale, without investing in new exon microarray technologies.Alternative splicing produces a variety of mRNA transcripts from a single gene by splicing...

2009-04-06 09:41:00

New RNA therapy reversed hemophilia in mice GAITHERSBURG, Md., April 6 /PRNewswire/ -- VIRxSYS Corporation announced today the publication of a new research article, "Trans-splicing into Highly Abundant Albumin Transcripts for Production of Therapeutic Proteins In Vivo," in the journal Molecular Therapy. The study describes a novel RNA therapy technique in which an RNA molecule that is inserted into the albumin gene "hijacks" the albumin, causing it to produce the newly added gene's...

2009-03-17 11:29:50

Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs. The switch is a protein that, when in the "on" position, maintains the normal character of cells that line the surface of organs and body cavities. These epithelial cells are the type of cell from which most solid tumors arise. However, when the switch is turned "off" or absent, epithelial cells acquire...

2009-03-16 01:30:00

PARIS, March 16 /PRNewswire-FirstCall/ -- ExonHit Therapeutics (Alternext: ALEHT) today reported the publication in Lancet Oncology of a study conducted by Institut Gustave Roussy, which describes the identification of a deregulated cell function in breast cancer through the analysis of alternative RNA splicing [1]. Study data demonstrate that exons are differently expressed in malignant and benign lesions, and alternative transcripts determine the molecular characteristics of breast...

2009-02-09 07:45:54

Findings may lead to novel treatments for diseases resistant to current RNAi A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches. This may enable the development and discovery of a new class of drugs to treat a wide array of diseases. Critical to the technology is the approach this team took to specifically target RNA biosynthesis. The research findings are reported in the journal...