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Latest RNA splicing Stories

2009-03-17 11:29:50

Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs. The switch is a protein that, when in the "on" position, maintains the normal character of cells that line the surface of organs and body cavities. These epithelial cells are the type of cell from which most solid tumors arise. However, when the switch is turned "off" or absent, epithelial cells acquire...

2009-03-16 01:30:00

PARIS, March 16 /PRNewswire-FirstCall/ -- ExonHit Therapeutics (Alternext: ALEHT) today reported the publication in Lancet Oncology of a study conducted by Institut Gustave Roussy, which describes the identification of a deregulated cell function in breast cancer through the analysis of alternative RNA splicing [1]. Study data demonstrate that exons are differently expressed in malignant and benign lesions, and alternative transcripts determine the molecular characteristics of breast...

2009-02-09 07:45:54

Findings may lead to novel treatments for diseases resistant to current RNAi A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches. This may enable the development and discovery of a new class of drugs to treat a wide array of diseases. Critical to the technology is the approach this team took to specifically target RNA biosynthesis. The research findings are reported in the journal...

2009-02-03 15:28:57

A new therapy being developed at the University of Florida could, in time, produce another weapon for the fight against herpes.The gene-targeting approach uses a specially designed RNA enzyme to inhibit strains of the herpes simplex virus. The enzyme disables a gene responsible for producing a protein involved in the maturation and release of viral particles in an infected cell. The technique appears to be effective in experiments with mice and rabbits, but further research is required before...

2009-01-29 08:58:51

U1, which guides the cell's RNA splicing machinery, 'slides' one RNA base, explaining a mysterious mutationTwo molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia (PCH). The new findings were published online, ahead of print, on January 25th in the journal Nature Structural and Molecular Biology.Typically striking during early...

2008-12-26 06:43:20

An international research team led by Tim Nilsen, Ph.D., a professor of medicine and biochemistry and the director of the School of Medicine's Center for RNA Molecular Biology, has discovered an unexpected mechanism governing alternative splicing, the process by which single genes produce different proteins in different situations. The new mechanism suggests that curing the more than half of genetic diseases that are caused by mutations in the genetic code that in turn create mistakes in...

2008-08-13 18:00:14

By Ponomarev, Vladimir Recent years have witnessed a remarkable increase in our knowledge and understanding of the genetics and molecular biology of human diseases. During the past 2 decades, technologic innovations revolutionized molecular and cell biology. Significant progress in the understanding of the molecular-genetic mechanisms of many diseases has been achieved with the advent of the modern molecular- biologic assays. The development of transgenic animal models of human diseases,...

2008-07-02 00:00:22

About 600 Verizon telephone customers lost service in the East End of Charleston sometime Saturday after underground cables were damaged, a spokesman said. Repairs were expected to start today but may not be completed until Thursday, Verizon spokesman Harry Mitchell said Sunday. The damage occurred along Washington Street between Elizabeth and Maxwell streets, "almost directly in front of the Delish Express," he said, and affects customers who live or work in that area. "Apparently the...

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2008-04-09 09:00:00

Splicing exerts selective pressure on DNA sequenceThe Human Genome Project revealed that only a small fraction of the 3 billion "letter" DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events? Scientists from Cold Spring Harbor Laboratory (CSHL) and the...

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2007-03-20 08:20:00

Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new RNA molecules. Their results provide insight into what may have been the first self-replicating molecule to arise billions of years ago on the evolutionary path toward the emergence of life. In all forms of life known today, the synthesis of DNA and RNA molecules is carried out by enzymes made of...


Word of the Day
cenobite
  • One of a religious order living in a convent or in community; a monk: opposed to anchoret or hermit (one who lives in solitude).
  • A social bee.
This word comes from the Latin 'coenobium,' convent, which comes from the Greek 'koinobios,' living in community.
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