Latest RNA splicing Stories
Water, that molecule-of-all-trades, is famous for its roles in shaping the Earth, sustaining living creatures and serving as a universal solvent.
Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns).
Pre-messenger RNA (pre-mRNA) splicing is an integral step in gene expression, removing introns that would otherwise disrupt the coding potential of gene transcripts.
In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate). Scientists long have thought the transformation of pre-mRNA into mature mRNA--called splicing--happens only in a cell's nucleus.
A modification to an "ace" gene prediction program now enables scientists to predict the very beginnings of gene transcription start sites and where the first splice occurs thereby defining the first exon of the gene.
One of the key motivations for revisiting the probability of life elsewhere in the universe is the surprising proclivity of life in hostile places on Earth. New findings suggest that modern organisms may have useless DNA fragments today that once saved their ancestors lives in extreme environments.
- A volcanic mudflow.