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Latest RNA splicing Stories

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2006-08-23 08:59:08

Water, that molecule-of-all-trades, is famous for its roles in shaping the Earth, sustaining living creatures and serving as a universal solvent. Now, researchers at the University of Michigan and the Academy of Sciences of the Czech Republic have uncovered two previously unknown roles for water in RNA enzymes, molecules which themselves play critical roles in living cells and show promising medical applications. The researchers' findings will be published online in the Proceedings of the...

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2005-08-22 14:15:00

PITTSBURGH -- Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a functional protein or, worse, produce an abnormal protein that interferes with normal cell...

2005-08-15 12:57:11

Pre-messenger RNA (pre-mRNA) splicing is an integral step in gene expression, removing introns that would otherwise disrupt the coding potential of gene transcripts. As published in the August 15th issue of G&D, Drs. Tommaso Villa and Christine Guthrie at UCSF have identified a novel splicing fidelity factor, as well as provide additional evidence for a two-step model of pre-mRNA splicing. The researchers found that deletion of the yeast gene ISY1 reduces the efficiency of the first step...

2005-08-11 19:20:00

SALT LAKE CITY -- In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate). Scientists long have thought the transformation of pre-mRNA into mature mRNA--called splicing--happens only in a cell's nucleus. But using stem cells from human umbilical cord blood to engineer the...

2005-07-12 02:05:00

A modification to an "ace" gene prediction program now enables scientists to predict the very beginnings of gene transcription start sites and where the first splice occurs thereby defining the first exon of the gene. The modification to the gene prediction software TWINSCAN is called N-SCAN. Michael Brent, Ph.D. professor of computer science at Washington University in St. Louis, together with Samuel S. Gross, then an undergraduate at Washington University, and Randall H. Brown, Ph.D., a...

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2005-02-25 07:15:00

One of the key motivations for revisiting the probability of life elsewhere in the universe is the surprising proclivity of life in hostile places on Earth. New findings suggest that modern organisms may have useless DNA fragments today that once saved their ancestors lives in extreme environments. Astrobiology Magazine -- Yale scientists report in the journal Nature that the "missing" genes for tRNA in an ancient parasite are made up by splicing together sequences in distant parts of the DNA...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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