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Latest RNA Stories

2014-01-27 13:30:39

A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously...

Mitochondrial Ribosome Deciphered
2014-01-24 13:37:28

ETH Zurich Researchers at the Swiss Federal Institute of Technology (ETH) in Zurich have deciphered the structure of part of the ribosome found in mitochondria, the power plants of the cell. The scientists were able to benefit from advancements in the field of electron microscopy and capture images of the mitochondrial ribosome at a level of resolution never achieved before. The ribosome can be thought of as a decryption device housed within the cell. It is able to decipher the genetic...

2014-01-15 08:28:43

WOONSOCKET, R.I., Jan. 15, 2014 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB) has filed a U.S. provisional patent application concerning composition of matter, biological targets, mechanism of action, methods and formulations to achieve targeted tumor cell death. This patent application describes a novel class of very small noncoding double stranded RNA molecules (VSRNAs) which interfere with the basic homeostatic cellular processes in tumor cells....

2014-01-14 08:28:37

WESTBOROUGH, Mass., Jan. 14, 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted technologies, today announced that it received the Notice of Allowance from the United States Patent and Trademark Office on its unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. The patent covers the...

2014-01-13 08:27:16

-Regulus microMarkers(TM) Designed to Support Regulus' Therapeutic Pipeline, its Collaborators and Strategic Partners- LA JOLLA, Calif., Jan. 13, 2014 /PRNewswire/ -- Regulus Therapeutics Inc. (NASDAQ:RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today that it has established Regulus microMarkers(TM), a new research and development division of Regulus designed to support the expansion of its innovative...

Isolating RNA From Live Cells In Their Natural Tissue Environment
2014-01-13 07:23:08

University of Pennsylvania School of Medicine Findings allow for better understanding of how tissue microenvironment affects gene expression in healthy and diseased cells A multi-disciplinary team from the University of Pennsylvania have published in Nature Methods a first-of-its-kind way to isolate RNA from live cells in their natural tissue microenvironment without damaging nearby cells. This allows the researchers to analyze how cell-to-cell chemical connections influence individual...

2014-01-13 04:21:08

New Preclinical Results in Non-Human Primates Demonstrate Significant and Sustained Reduction of Transthyretin Using its Proprietary LUNARTM Delivery Technology SAN DIEGO, Jan. 13, 2014 /PRNewswire/ -- Arcturus Therapeutics, Inc., an industry leader in RNA technologies, today announced its flagship program - an RNAi therapeutic targeting transthyretin (TTR)-mediated amyloidosis. Preclinical non-human primate data will be presented at the Biotech Showcase being held January 13, 2014...

2014-01-10 08:23:49

SEATTLE, Jan. 10, 2014 /PRNewswire/ -- PhaseRx, Inc., an RNA therapeutics company, today announced the appointment of Michael Houston, Ph.D., as its Vice President, Therapeutics Development. (Logo: http://photos.prnewswire.com/prnh/20140110/SF44129LOGO) Dr. Houston brings more than two decades of experience in the manufacturing and development of peptide and oligonucleotide-based therapeutics to PhaseRx. He has directed numerous programs ranging from research to GMP manufacture of...

2014-01-10 08:23:28

HOERSHOLM, Denmark and SAN DIEGO, Jan. 10, 2014 /PRNewswire/ -- Santaris Pharma A/S has announced today that they have signed an agreement with GlaxoSmithKline (GSK), whereby, pursuant to an option right, GSK gains access to Santaris' Locked Nucleic Acid (LNA) technology to develop RNA-targeted medicines. Under the terms of the agreement, GSK can obtain rights to utilize Santaris Pharma's proprietary Locked Nucleic Acid (LNA) Drug Platform to research, develop and commercialize...

2014-01-08 12:29:45

LONDON, Jan. 8, 2014 /PRNewswire/ -- Reportbuyer.com just published a new market research report: Global Analysis of MicroRNA Tools and Services Market Evolving microRNA Market Provides an Opportunity for Vendors of qRT-PCR and Functional ToolsThe study covers the analysis and forecasts of MicroRNA tools and services market globally for the period 2009 to 2017. The market is broadly classified into 2 major segments - tools and services. MicroRNA tools market is further segmented...


Latest RNA Reference Libraries

Brief Introduction To DNA Probes
2014-01-12 00:00:00

DNA probes help scientists to detect a specific gene in a long DNA sequence. According to Dr. Michael A. Pfaller, DNA probes are “single-stranded pieces of nucleic acid, labeled with a specific tracer (isotope, enzyme, or chromophore), that will hydrogen bond (hybridize) with complementary single-stranded pieces of DNA (or RNA) under the appropriate conditions of pH, temperature, and iconic strength.” The Foundation for Genomics and Population Health website has a helpful video about...

Caenorhabditis elegans
2014-01-12 00:00:00

Caenorhabditis elegans is a species of parasitic roundworm in the Nematoda phylum. It can be found in temperate regions, in many different areas of the world. It prefers to reside in nutrient rich soils. Its scientific name is derived from the Greek terms Caeno, meaning recent, rhabditis, meaning rod-like, and the Latin term elegans, which means elegant. It was first named by Maupas in 1900, but was not classified in the Caenorhabditis subgenus until 1952 by Osche. Caenorhabditis elegans...

Proceedings of the National Academy of Sciences
2012-05-29 11:19:42

The Proceedings of the National Academy of Sciences of the United States of America (PNAS) is a peer-reviewed scientific journal established in 1914 as the official journal of the US National Academy of Sciences. The first managing editor of the journal was mathematician Edwin Bidwell Wilson. As of May 2012, the editor-in-chief is Inder M. Verma. PNAS is published weekly in print, and daily online in PNAS Early Edition. The first issue of PNAS was published in 1915, and the journal...

Biophysical Journal
2012-05-28 10:08:02

The Biophysical Journal is a peer-reviewed scientific journal published biweekly by Cell Press on behalf of the Biophysical Society. It was established in 1960. The editor-in-chief is Edward Egelman. It covers all aspects of biophysics.  It is the leading international journal for original research in molecular, cellular, and system biophysics. Modern biophysics is a broad and rapidly advancing field encompassing the study of biological structures with a focus on mechanisms at the...

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Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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