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Latest Rofecoxib Stories

2008-08-19 12:01:01

A new study asserts that a 1999 Vioxx clinical drug trial sponsored by Merck & Co. was done to support a marketing campaign, U.S. researchers said. "You hear people talk about it, but I've never seen anyone ... formally admit to it," Arthur Caplan, a University of Pennsylvania bioethicist told The Wall Street Journal Tuesday. The 1999 drug study included roughly 5,500 patients, the Journal reported. The new study, published in the Annals of Internal Medicine, includes quotes of Merck...

2008-08-09 03:00:00

By Januzzi, James L Jr In May 1999, the US Food and Drug Administration approved rofecoxib, the first nonsteroidal antiinflammatory drug (NSAID)1 with specific cyclooxygenase II (COX-II) activity. Soon to follow were the approvals of other COX-II inhibitors, including celecoxib. The hypothetical advantage of COX-II inhibitors over standard NSAIDs was that COX-II inhibitors reportedly caused fewer gastrointestinal complications, thanks to their avoidance of COX-I inhibition. Not long after...

2008-08-09 03:00:08

By Brune, Kay Katus, Hugo A; Moecks, Joachim; Spanuth, Eberhard; Jaffe, Allan S; Giannitsis, Evangelos BACKGROUND: We investigated whether higher concentrations of N- terminal pro-B-type natriuretic peptide (NT-proBNP) predicts cardiovascular adverse events (CV-AEs) in patients with osteoarthritis treated with antiinflammatory drugs. METHODS: NT- proBNP was measured in baseline samples from 433 patients enrolled in a prospective randomized study designed to test the therapeutic effect of a...

2008-07-30 18:00:00

By Phil Kabler Prescription data mining is a multibillion-dollar-a-year industry that, among other uses, allows pharmaceutical companies to pitch pricey brand-name drugs directly to individual doctors based on their prescribing habits. On Tuesday, industry and medical officials debated the pros and cons of data mining - and whether the Legislature should crack down on the practice in West Virginia. "Prescription data mining is like a global positioning system for drug reps - providing...

2008-07-18 09:00:49

Despite higher ticket prices and a sluggish economy, passenger traffic was up almost 4 percent at Newport News/Williamsburg International Airport during the first half of 2008. A total of 515,954 people flew through the airport during the past six months. The airport handled 496,922 passengers during the first six months of 2007. Airport spokeswoman Jessica Wharton said that, despite the strong numbers, it's difficult to predict where the industry is headed. "We're going into uncharted...

2008-06-27 06:01:47

By Dickinson, James G THE FDA SAYS it has found at least two fundamental problems with data in a Harvard study, found in the New England Journal of Medicine, that showed drugs approved close to their Prescription Drug User Fee Act (PDUFA) deadline are more likely to have post- market safety problems than other drugs. The study, from researchers at Harvard Medical School and Brigham and Women's Hospital, noted that their findings "are not consistent with" FDA analyses in 2005 that "showed no...

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2008-06-26 00:10:00

Older women will now have to wait longer to be vaccinated against cervical cancer. U.S. regulators denied Merck & Co.'s application to market Gardasil to women ages 27 through 45. In a letter to Merck, the U.S. Food and Drug Administration said its review of the vaccine found "issues" that preclude approval within the expected review time frame. "It's hard to get a feel for if this is a dead issue or if this is delayed," said Linda Bannister, an analyst for Edward Jones. "At the...

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2008-06-02 00:10:00

Researchers from M.D. Anderson Cancer Center in Houston reported Sunday that high doses of the arthritis medication Celebrex might prevent lung cancer in heavy smokers. The drug works by inhibiting the COX-2 enzyme that causes inflammation, which has been linked to cancer. The researchers studied 212 heavy smokers and discovered that those who took a high dose of Celebrex, also known as celecoxib, had less of a certain type of precancerous lung cell changes compared with those who took...

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2008-05-30 16:00:00

An appeals court in Texas reversed a $26.1 million verdict against drugmaker Merck & Co. Inc., finding no evidence that its popular painkiller Vioxx was responsible for the blood clot that triggered a fatal heart attack in Robert Ernst, the plaintiff's husband. Ernst had been taking the now-withdrawn drug for eight months before his death in May 2001. The ruling reverses a 2005 verdict in which a Texas jury found Vioxx responsible for Mr. Ernst's heart attack, and awarded his widow $235...

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2008-04-16 00:10:00

The painkiller Vioxx has been the concern of two new reports about how drug companies influence the interpretation and publication of medical research. The recent reports say Merck & Co. used ghostwriting to publish several research articles on the drug. The report claims the company frequently paid academic scientists to take credit for the articles. They also contend Merck tried to minimize deaths in two studies that showed that the now withdrawn Vioxx didn't work at treating or...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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