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Last updated on April 24, 2014 at 16:36 EDT

Latest Ryanodine receptor Stories

2014-01-20 12:27:55

Researchers have discovered the fundamental biology of calcium waves in relation to heart arrhythmias. The findings published this month in the January 19 edition of Nature Medicine outlines the discovery of this fundamental physiological process that researchers hope will one day help design molecularly tailored medications that correct the pathophysiology. Heart arrhythmias cause the heart to beat irregularly, resulting in symptoms such as dizziness and fainting, or in severe cases,...

2013-11-06 08:28:37

TARRYTOWN, N.Y. and COARSEGOLD, Calif., Nov. 6, 2013 /PRNewswire/ -- ARMGO Pharma and the Kennedy's Disease Association (KDA) today announced that a research grant has been awarded to support preclinical work on novel, orally available compounds that have potential as a novel treatment for Kennedy's Disease (also known as Spinal Bulbar Muscular Atrophy or SBMA). The project being advanced by ARMGO Pharma is focused on a novel class of small molecule drugs known as Rycals(®) which target the...

2012-02-01 23:36:46

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. The findings appear in the latest issues of the journals Nature and Journal of Biological Chemistry. "These are exquisite three-dimensional objects, and the structures...

2012-01-11 06:35:23

(Ivanhoe Newswire) -- A young fit athlete who appears no different from the others on his football team dies suddenly during practice on a hot summer day. What could make this happen? According to new studies some physically fit young people could have a genetic mutation that makes them more sensitive to heat. Researchers led by those at Baylor College of Medicine may have identified a molecule that could reduce that threat. Dr. Susan Hamilton chair of molecular physiology and biophysics...

Experimental 'Couch Potato Pill' May Also Prevent Heat Stroke
2012-01-09 14:12:48

According to a new study in the journal Nature Medicine, an experimental treatment known as the 'couch potato pill' may also help to prevent heatstroke in people genetically predisposed to it. The pill first received its name due its ability to mimic the effects of exercise in inactive laboratory mice, eliciting much excitement in the medical community that it might eventually prove useful in activity-disinclined human patients as well. Yet new research shows that the drug, known to...

2011-08-02 19:54:25

There is a reason exercise becomes more difficult with age. A report in the August Cell Metabolism, a Cell Press publication, ties the weakness of aging to leaky calcium channels inside muscle cells. But there is some good news: the researchers say a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks. Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come...

2011-05-02 07:00:00

TARRYTOWN, N.Y., May 2, 2011 /PRNewswire/ -- ARMGO Pharma Inc., has appointed Dr. Sapan Shah as Chief Executive Officer, effective immediately. Dr. Shah joins ARMGO from Shionogi Inc., where he served as President and Chief Executive Officer since 2002. In addition to his role as CEO, Dr. Shah will also join ARMGO Pharma's Board of Directors. Dr. Shah commented: "I am very excited to be joining an organization of such high caliber as ARMGO Pharma Inc. The company has made tremendous...

2011-03-09 14:40:50

Pacemaker cells in the sinoatrial node control heart rate, but what controls the ticking of these pacemaker cells? New research by Angelo Torrente and his colleagues of the M.E. Mangoni group's, reveals, for the first time, a critical functional interaction between Cav1.3 calcium ion (Ca2+) channels and ryanodine-receptor (RyR) mediated Ca2+ signaling. The study also sheds light on a long-standing debate regarding the relative contributions of the 'funny current' generated by ion channels and...

2010-12-13 21:10:37

Researchers have provided the first thorough mechanistic account of how a genetic defect leads to malignant hypothermia (MH) and central core disease (CCD), rare genetic skeletal muscle disorders. The study appears in the January issue of the Journal of General Physiology (www.jgp.org). Mutations in the type 1 ryanodine receptor (RYR1), the calcium release channel of the sarcoplasmic reticulum (SR) activated during skeletal muscle excitation-contraction (EC) coupling, give rise to CCD. One of...

2010-11-29 14:35:08

Scientists from Germany, UK and Italy identify a molecular switch that leads to a sustained increase of calcium in nerve cells and plays a crucial role in the formation of memory and addictive behaviors. Learning and memory formation are based on the creation of new connections between neurons in the brain. Also, behaviors such as nicotine addiction manifest themselves in long-term changes of neuronal connectivity and can "“ at least in this respect "“ be viewed as a form of...