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Latest Sclerostin Stories

2014-01-01 16:20:13

THOUSAND OAKS, Calif. and BRUSSELS, Jan. 1, 2014 /PRNewswire/ -- Amgen (NASDAQ:AMGN) and UCB (Euronext Brussels:UCB) today announced results from a Phase 2 trial evaluating romosozumab (AMG 785/CDP7851) in postmenopausal women with low bone mineral density (BMD). Published in the New England Journal of Medicine (NEJM), the trial demonstrated that, compared with placebo, romosozumab treatment for 12 months significantly increased BMD at the lumbar spine, total hip and femoral neck....

2013-04-17 17:27:26

Study results suggest combination treatments may be needed to stop bone loss, fuel growth Although the drug zoledronic acid slows bone loss in osteoporosis patients, it also boosts levels of a biomarker that stops bone formation, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Osteoporosis weakens bones and increases the risk patients will suffer fractures. The findings suggest combination therapy...

2012-08-29 23:02:35

Kettlebell trainer Lorna Kleidman supports an article for Med Page Today which focuses on how the bone health of premenopausal women is improved through weekly bouts of moderate exercise. Bohemia, NY (PRWEB) August 28, 2012 On August 28th, Lorna Kleidman, creator of the kettlebell training program KettleX, reacts to an article published for Med Page Today which discusses how bone health in premenopausal women can be improved by moderate physical activity. According to the article, a study...

2012-08-16 00:47:00

New study shows physical activity reduces hormone that inhibits bone formation A study to be published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM) suggests that physical activity for premenopausal women is very effective in reducing sclerostin–a known inhibitor of bone formation. In addition, physical training enhances IGF-1levels, which have a very positive effect on bone formation. Bone is a tissue that is always changing due to hormonal...

2012-05-31 01:31:03

Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells. Mammary stem cells produce various kinds of breast cell types. They may also drive the development and growth of malignant breast tumors. Published recently in the Journal of Biological Chemistry, the research also suggests that a new signaling pathway may be involved, a...

2011-07-07 09:20:54

Study outcomes may also provide future direction for the development of drugs to combat osteoporosis, bone fractures Astronauts lose a significant amount of bone mass during space travel and with long duration flights there is concern that this bone loss could lead to an increased risk of fractures. When the final mission of NASA's 30-year Space Shuttle program is launched on July 8, an animal experiment to test a novel therapy to increase bone mass will be on board. Led by a consortium of...

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2011-07-06 14:26:02

The University of Colorado Boulder is involved with five different space science payloads ranging from antibody tests that may lead to new bone-loss treatments to an experiment to improve vaccine effectiveness for combating salmonella when Atlantis thunders skyward July 8 on the last of NASA's 135 space shuttle missions. One experiment, sponsored by the global pharmaceutical companies Amgen and UCB, will test an antibody to sclerostin -- a protein that has a negative effect on bone formation,...

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2011-07-06 11:20:00

Researchers in the University of North Carolina at Chapel Hill/North Carolina State University Joint Department of Biomedical Engineering will be at the Kennedy Space Center for the last space shuttle launch of the NASA program as Atlantis departs for its final mission into Earth's orbit. With July 8, 2011 as the target launch date, the UNC/NCSU team led by Ted Bateman, PhD, associate professor in the department, have painstakingly prepared an experiment aboard Atlantis aimed at revealing...

2011-07-05 15:31:00

Thousand Oaks, Calif. and BRUSSELS, July 5, 2011 /PRNewswire/ -- Amgen (NASDAQ: AMGN) and UCB (Euronext Brussels: UCB) announced today that they are collaborating with the National Aeronautics and Space Administration (NASA) Ames Research Center to conduct a preclinical test of a sclerostin antibody in an experiment that will take place aboard space shuttle Atlantis, on the final NASA shuttle mission, Space Shuttle Flight STS-135, scheduled to launch July 8, 2011. The loss of bone mass...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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