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Last updated on April 23, 2014 at 1:22 EDT

Latest Scripps Research Institute Stories

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

Scientists Uncover Most Detailed Picture Of Muscular Dystrophy Defect
2014-01-02 11:27:09

The Scripps Research Institute Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease. “This the first time the structure of the RNA defect that causes this disease has been determined,” said TSRI Associate Professor Matthew...

Scientists Use Screening Strategy To Identify Compound With Promise For Obesity-linked Diabetes
2013-12-23 07:01:51

Scripps Research Institute Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes. At the same time, they were able to identify the...

2013-12-22 23:01:04

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. La Jolla, CA (PRWEB) December 22, 2013 Scripps Research Institute Scientists Use Method to Identify Compound with Promise for Obesity-Linked Diabetes LA JOLLA, CA—December 22, 2013—Scientists at The Scripps Research Institute (TSRI) have...

2013-12-09 10:06:30

The avian H7N9 influenza virus that emerged earlier this year in China is poorly adapted for sustained transmission between humans, suggesting that the current form of the virus is unlikely to cause a pandemic, according to a new study led by Ian A. Wilson, Ph.D., and James C. Paulson, Ph.D., of The Scripps Research Institute (TSRI). The study, published yesterday in Science, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of...

Emerging Bird Flu Strain Still Poorly Adapted For Infecting Humans
2013-12-05 19:41:56

Scripps Research Institute Avian influenza virus H7N9, which killed several dozen people in China earlier this year, has not yet acquired the changes needed to infect humans easily, according to a new study by scientists at The Scripps Research Institute (TSRI). In contrast to some initial studies that had suggested that H7N9 poses an imminent risk of a global pandemic, the new research found, based on analyses of virus samples from the Chinese outbreak, that H7N9 is still mainly adapted...

Hepatitis C Vaccine Efforts Bring Vaccine Closer To Reality
2013-11-30 05:22:41

redOrbit Staff & Wire Reports - Your Universe Online A hepatitis C vaccine is one step closer thanks to the efforts of scientists at The Scripps Research Institute (TSRI), who have managed to discover unexpected structural features of a protein used by the virus to infect liver cells. The study authors, whose work appears in Friday’s edition of the journal Science, state any successful hepatitis C vaccine would most likely target this protein, which is known as E2 envelope...

2013-11-05 08:34:27

SAN DIEGO, Nov. 5, 2013 /PRNewswire/ -- Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) announced today that it has entered into an antibody and vaccine development collaboration with The Scripps Research Institute (TSRI) of La Jolla, CA. Under the terms of the agreement, Sorrento obtains an exclusive, worldwide license to TSRI's novel technologies based on ghrelin signaling inhibition for the prevention and treatment of obesity and other metabolic disorders. A research group...

2013-11-04 16:29:43

LA JOLLA, Calif., Nov. 4, 2013 /PRNewswire/ -- The generic drug gabapentin, which is already widely prescribed for epilepsy and some kinds of pain, appears to be safe and effective in the treatment of alcohol dependence. The finding comes from a 150-patient randomized, placebo-controlled, double blind clinical trial conducted by scientists at The Scripps Research Institute (TSRI). "Gabapentin's effect on drinking outcomes is at least as large or greater than those of existing...

2013-10-31 16:26:03

The finding represents a scientific feat as well as progress toward an HIV vaccine LA JOLLA, Calif., Oct. 31, 2013 /PRNewswire/ -- Collaborating scientists at The Scripps Research Institute (TSRI) and Weill Cornell Medical College have determined the first atomic-level structure of the tripartite HIV envelope protein--long considered one of the most difficult targets in structural biology and of great value for medical science. The new findings provide the most detailed picture yet...