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Latest Secretion Stories

2014-02-10 11:17:25

Twenty proteins specifically secreted by primary effusion lymphoma cell lines identified, according to new research published in The American Journal of Pathology Primary effusion lymphoma (PEL) is a rare B-cell neoplasm distinguished by its tendency to spread along the thin serous membranes that line body cavities without infiltrating or destroying nearby tissue. By growing PEL cells in culture and analyzing the secretome (proteins secreted into cell-conditioned media), investigators have...

Intracellular ABC Transporters Allow Leaf Beetle Larvae To Accumulate Defensive Substances When Feeding
2013-12-09 11:58:38

Max Planck Institute for Chemical Ecology Similar membrane proteins play a crucial role in the transport of toxic substances out of the cell Scientists at the Max Planck Institute for Chemical Ecology in Jena, Germany, have discovered the decisive biological stimulator for the accumulation of defensive substances in leaf beetle larvae used by the insects to fend off predators: ABC transport proteins, which are found in large quantities in glandular cells of the larvae. The poplar leaf...

2013-10-24 10:26:37

Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine (BUSM) and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made. These findings are published as a Letter in Nature (Park, E. et al. 2013)....

Role That Flagellum Plays In Helping E. Coli Colonize Rough Surfaces Revealed
2013-04-11 13:06:15

Harvard University New research from Harvard University helps to explain how waterborne bacteria can colonize rough surfaces–even those that have been designed to resist water. A team of materials scientists and microbiologists studied the gut bacterium Escherichia coli, which has many flagella that stick out in all directions. The researchers found that these tails can act as biological grappling hooks, reaching far into nanoscale crevices and latching the bacteria in place....

2012-12-06 11:19:38

Combining 2 methods provides a real-time view of bedbug chemical signals Bed bugs exchange specific chemical signals corresponding to particular behaviors, and researchers have now combined two unusual technologies to sniff out these signals in a matter of seconds. The results are published December 5 in the open access journal PLOS ONE by Ole Kilpinen and colleagues from Aarhus University, Denmark, and reveal previously unknown aspects of bed bug lifestyles and mating behaviors....

2012-10-19 01:44:17

Chemists at the California Institute of Technology (Caltech) have managed, for the first time, to simulate the biological function of a channel called the Sec translocon, which allows specific proteins to pass through membranes. The feat required bridging timescales from the realm of nanoseconds all the way up to full minutes, exceeding the scope of earlier simulation efforts by more than six orders of magnitude. The result is a detailed molecular understanding of how the translocon works....

2012-06-07 06:28:11

CINCINNATI, June 7, 2012 /PRNewswire-USNewswire/ -- Scientists have discovered a new function for a protein that protects cells during injury and could eventually translate into treatment for conditions ranging from cardiovascular disease to Alzheimer's. (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) Researchers report June 7 in the online edition of Cell that a type of protein called thrombospondin activates a protective pathway that prevents heart cell damage in mice...

2012-05-10 13:55:04

Journal of Biological Chemistry: Mechanism of bacterial transport system published In order to interact with the environment, bacteria secrete a whole arsenal of proteins. Researchers have now found how one of the transportation systems used for this purpose — the type VI secretion system — works for the single-celled organism Agrobacterium tumefaciens. They have identified the relevant transport proteins and their energy suppliers. With colleagues at the Academia Sinica in...

2012-03-19 06:22:08

SUNNYVALE, Calif., March 19, 2012 /PRNewswire/ -- Amarantus BioSciences, Inc. (OTCBB: AMBS), a biotechnology company developing MANF, a first-in-class disease-modifying therapeutic protein being advanced for the treatment of Parkinson's Disease, today reported that it has added several new scientific articles on its lead therapeutic candidate MANF to its website, bringing the total number of articles listed on its website to 20. A listing of the citations can be viewed on the Company's...

Some Bacteria Attack Using Poison Daggers
2012-02-27 10:00:41

[ Watch the Video ] Bacteria have evolved different systems for secreting proteins into the fluid around them or into other cells. Some, for example, have syringe-like exterior structures that can pierce other cells and inject proteins. Another system, called a type VI secretion system, is found in about a quarter of all bacteria with two membranes. Despite being common, researchers have not understood how it works. Now a team, co-led by researchers at the California Institute of...


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2011-04-14 14:17:06

Agrobacterium tumefaciens is the causal agent of crown gall disease (the formation of tumours) in over 140 species of dicot. It is rod shaped. Symptoms are caused by the insertion of a small segment of DNA into the plant cell. It is an alphaproteobacterium of the family Rhizobiaceae which includes the nitrogen fixing legume symbionts. They are pathogenic and provide no benefit to the plant. It also affects a wide variety of plants. In an economical sense it affects walnuts, grape vines,...

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