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Latest Senile plaques Stories

2011-07-03 12:35:02

Highly aggregative and neurotoxic amyloid peptide Abeta43 points the way to new approaches for AD diagnosis and treatmentTokyo, July 4, 2011 - (ACN Newswire) - Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease (AD). Their surprising findings reveal that the peptide is more abundant, more neurotoxic, and exhibits a higher propensity to aggregate than amyloidogenic...

2011-04-27 15:07:29

VA-USF study finds cotinine reduces the brain plaques associated with dementia Cotinine, a compound derived from tobacco, reduced plaques associated with dementia and prevented memory loss in a mouse model of Alzheimer's disease, a study led by researchers at Bay Pines VA Healthcare System and the University of South Florida found. The findings are reported online in the Journal of Alzheimer's Disease in advance of print publication. "We found a compound that protects neurons, prevents the...

2010-12-16 14:54:06

APOE4 genotype linked to functional changes prior to formation of senile plaques People with a known, high risk for Alzheimer's disease develop abnormal brain function even before the appearance of telltale amyloid plaques that are characteristic of the disease, according to a new study. Researchers at Washington University School of Medicine in St. Louis report in the Dec. 15 issue of The Journal of Neuroscience that these patients had a particular form of the apolipoprotein E (APOE) gene...

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2010-09-17 15:09:03

By Jim Dryden, Washington University in St. Louis An international team of Alzheimer's disease experts, led by Washington University School of Medicine in St. Louis, has uncovered a gene variation that appears to predict the rate at which Alzheimer's disease will progress. The investigators report their findings online in the journal Public Library of Science (PLoS) Genetics. Whereas previous studies have focused on factors that influence the risk for Alzheimer's, the new research points to a...

2009-11-11 18:05:06

Protein reduces levels of amyloid beta and tau hyperphosphorylation, 2 hallmarks of Alzheimer's Investigators at Burnham Institute for Medical Research (Burnham) and colleagues have identified a novel mouse gene (Rps23r1) that reduces the accumulation of two toxic proteins that are major players in Alzheimer's disease: amyloid beta and tau. The amyloid and tau lowering functions of this gene were demonstrated in both human and mouse cells. Amyloid beta is responsible for the plaques found in...

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2009-01-22 11:29:17

A growing body of evidence demonstrates that we can take steps to delay age-related cognitive decline, including in some cases that which accompanies Alzheimer's disease, according to a study published in the January 2009 issue of the Journal of Alzheimer's Disease. Thomas B. Shea, PhD, of the Center for Cellular Neurobiology; Neurodegeneration Research University of Massachusetts, Lowell and his research team have carried out a number of laboratory studies demonstrating that drinking apple...

2008-10-30 00:00:15

Neurological markers for Alzheimer's disease are exacerbated in brains of mice fed a diet rich in animal fat and poor in omega-3, Canadian researchers say. A University of Laval research team led by Frederic Calon used a type of transgenic mice that produce two proteins found in the brains of Alzheimer patients -- tau proteins -- which prevent proper neuron functioning, and amyloid-beta, associated with the formation of senile plaques within the brains of afflicted patients. The...

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2008-06-09 09:45:00

Alzheimer's disease isn't inevitable, suggests unique case in Neurobiology of AgingA 115-year-old woman who remained mentally alert throughout her life had an essentially normal brain, with little or no evidence of Alzheimer's disease, according to a study in the August issue of Neurobiology of Aging.The findings question the assumption that Alzheimer's disease or other forms of dementia will inevitably develop, if people live long enough. "Our observations suggest that, in contrast to...

2005-11-22 16:29:54

Using a nuclear magnetic resonance technique, University of Illinois at Chicago chemists have obtained the first molecular-level images of precursors of bundled fibrils that form the brain plaques seen in Alzheimer's disease. Untangling the molecular structure of these pre-fibril forms, which may be the key neurotoxins in Alzheimer's, may help identify targets for new drugs to combat many neurodegenerative diseases. Microscopic bundled fibrils made of proteins called amyloid-beta are...

2005-11-16 14:45:57

GAINESVILLE, Fla. - Researchers with the University of Florida and the California Institute of Technology have developed a new strain of genetically modified mice that allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease. The development, reported Nov. 15 in the international open-access medical journal PloS Medicine, has helped scientists evaluate the brain's ability to repair one of Alzheimer's hallmark lesions, senile plaque. These plaques occur...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.