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Latest Sialic acid Stories

2012-06-11 11:53:36

Technique will help scientists understand how cells' common sugar molecules influence inflammation, cancer metastasis, and related conditions Scientists at The Scripps Research Institute have developed chemical compounds that can make key modifications to common sugar molecules ("glycans"), which are found on the surface of all cells in our body. The new study presents powerful new tools for studying these molecules' function, for example in cell signaling and immunity, and for...

2012-01-27 10:48:03

A team of biologists at the University of York has made an important advance in our understanding of the way cholera attacks the body. The discovery could help scientists target treatments for the globally significant intestinal disease which kills more than 100,000 people every year. The disease is caused by the bacterium Vibrio cholerae, which is able to colonise the intestine usually after consumption of contaminated water or food. Once infection is established, the bacterium secretes a...

Image 1 - Sexual Selection By Sugar Molecule Helped Determine Human Origins
2011-10-11 03:46:42

Researchers at the University of California, San Diego School of Medicine say that losing the ability to make a particular kind of sugar molecule boosted disease protection in early hominids, and may have directed the evolutionary emergence of our ancestors, the genus Homo. The findings, published in this week's early online edition of the Proceedings of the National Academy of Sciences, are among the first evidence of a novel link between cell surface sugars, Darwinian sexual selection,...

2010-07-26 12:10:58

Researchers at the University of California, San Diego School of Medicine have discovered that a kind of sugar molecule common to chimpanzees, gorillas and other mammals but not found in humans provokes a strong immune response in some people, likely worsening conditions in which chronic inflammation is a major issue. This non-human sialic acid sugar is an ingredient in some biotechnology drugs, and may be limiting or undermining their therapeutic effectiveness in some patients, the...

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2009-07-13 10:55:00

Group B Streptococcus (GBS), a bacterial pathogen that causes sepsis and meningitis in newborn infants, is able to shut down immune cell function in order to promote its own survival, according to researchers at the University of California, San Diego School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Their study, published online July 13 in the Journal of Experimental Medicine, offers insight into GBS infection "“ information that may lead to new medical...

2009-06-10 10:55:03

The virus that causes winter vomiting disease invades cells by attaching to particular sugar molecules on the surface of the cells. This is the conclusion of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden. This result may be an important step in the development of a drug against the regular hospital-based epidemics caused by the virus.Winter vomiting disease is an infectious inflammation of the gastro-intestinal tract, which occurs principally during the...

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2008-12-23 11:35:00

Researchers at Griffith University's Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded 'viral tummy bug' or rotavirus. These highly-infectious viruses are the leading cause of severe diarrhea in young children, responsible for thousands of hospitalizations in the developed world, and hundreds of thousands of deaths each year in developing countries. Institute Executive...

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2008-02-19 09:20:00

Scientists at the University of York have characterized an important new step in the mechanism used by bacteria to evade our immune system. It is an "Ëœinvisibility cloak' which means that bacteria like Haemophilus influenzae, a common cause of ear infections in children, can move about the body without the risk of being attacked by the immune system. A multidisciplinary research team from the Departments of Biology and Chemistry at York have been studying how bacteria capture the...

2005-08-26 19:25:22

The malaria parasite Plasmodium falciparum uses different pathways to invade red blood cells, evading the body's immune system and complicating efforts to create effective vaccines against the disease. A research team led by Australia's Alan F. Cowman, an international research scholar with the Howard Hughes Medical Institute, has identified a gene that the parasite uses to switch back and forth between invasion pathways. Researchers from the Scripps Research Institute in La Jolla,...