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Latest Single-nucleotide polymorphism Stories

2010-04-25 12:29:00

REYKJAVIK, Iceland, April 25, 2010 /PRNewswire-FirstCall/ -- Cigarette smoking is a major cause of illness and death worldwide. But it is a complex behavior, and how much people smoke, how hard they find it to quit, and the impact of long-term smoking on health varies greatly among individuals. A substantial portion of this variability is genetic. Two years ago, deCODE discovered the first common, single-letter variation (SNP) in the sequence of the human genome, on chromosome 15q25,...

2010-03-23 09:44:16

Grapes are one of the world's most economically important fruit crops, but the woody perennial takes three years to go from seed to fruit, and that makes traditional breeding expensive and time-consuming. A team of Agricultural Research Service (ARS) researchers has found a way to speed things up by developing a way to identify genetic markers in the grapevine's genome that can be linked with specific traits, such as fruit quality, environmental adaptation, and disease and pest resistance....

2010-03-19 10:41:45

Researchers are only beginning to understand how individual variation in gene regulation can have a lasting impact on one's health and susceptibility to certain diseases. Now, an ambitious survey of the human genome has identified differences in the binding of master regulators called transcription factors to DNA that affect how genes are expressed in different people. The study, which is published in the March 18, 2010, issue of Science, looked at two common transcription factors. HHMI...

2010-03-01 15:46:48

Alcohol dependence (AD) is a complex disease for which both genetic and environmental factors affect susceptibility. Previous research had identified several genes associated with AD through linkage analysis or candidate-gene approaches. Findings from a genome-wide association study (GWAS) support an association between AD and a cluster of genes on chromosome 11. Results will be published in the May 2010 issue of Alcoholism: Clinical & Experimental Research and are currently available at...

2010-02-25 15:17:51

Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. The related report by Yang et al, "Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry," appears in the March 2010 issue of the Journal of Molecular Diagnostics. Warfarin is an anti-coagulant that is commonly used to prevent blood clots and embolism. However, warfarin dosing is...

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2010-02-19 14:55:00

A few minor variations in one gene may make a difference in athletic endurance, according to a new study from Physiological Genomics. The study found that elite endurance athletes were more likely to have variations of the NRF2 gene than elite sprinters. Non-elite endurance athletes were also more likely to have the genetic variations compared to sprinters, although the difference was not as pronounced. The study shows an association between the gene variation and endurance, but does not...

2010-02-18 08:58:21

Analyzing the genomic structure of five men descended from the hunter-gatherers of southern Africa "“ including famed South African Bishop Desmond Tutu "“ reveals surprising ways in which the genetic codes of these groups differ from others in the world and from each other, said a consortium of experts including those from Baylor College of Medicine in a report that appears today in the journal Nature. In the report, the group describes the fully sequenced genomes of an individual...

2010-02-04 14:38:11

Study finds association between genes that regulate maternal inflammatory response, bacterial vaginosis and preterm delivery In a study to be presented today at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting â“ž¢, in Chicago, researchers will show the use of haplotype tagging (hap-tag) single-nucleotide polymorphisms (SNPs) to study the relationship between genetic predispositions, an environmental factor - bacterial...

2010-01-26 13:26:17

Researchers challenge prevailing assumptions in interpreting genome-wide studies In the decade since the Human Genome Project produced the first map of DNA sequences in the human genome, scientists throughout the world have combed through genome data to identify genes and gene variants that cause human disease. A new study suggests that researchers may need to broaden their search farther afield to pinpoint rare but powerful disease-causing mutations. Researchers from two large genome...

2010-01-26 12:29:37

Scientists at Duke University Medical Center say they are now convinced that rare genetic variants "“ as opposed to more common ones "“ lie at the heart of the genetic component of most common diseases. The finding appearing in PLoS Biology, stems from a series of simulation studies, and challenges common interpretations of a multitude of genome-wide association studies (GWAS) that have identified thousands of single-DNA letter changes associated with greater risk of common...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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