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Latest Single-nucleotide polymorphism Stories

2013-08-26 11:55:31

Concealed within the vastness of the human genome, (comprised of some 3 billion base pairs), mutations are commonplace. While the majority of these appear to have neutral effect on human health, many others are associated with diseases and disease susceptibility. Reed Cartwright, a researcher at Arizona State University's Biodesign Institute, along with colleagues at ASU, Washington University and the Wellcome Trust Sanger Institute, Cambridge, UK, report on a new software tool known as...

2013-06-18 19:30:27

Similar genetic variations occur in both overweight newborns and obese adults, a large study finds. The results will be presented Tuesday at The Endocrine Society's 95th Annual Meeting in San Francisco. "Our data suggest that adult obesity and newborn adiposity share, in part, a common genetic background," said study lead author Reeti Chawla, MD, fellow in pediatric endocrinology at Ann & Robert H. Lurie Children's Hospital of Chicago and the Northwestern University Feinberg School of...

2013-06-11 21:08:00

Individuals of a particular species generally differ from one another. We are clearly most adept at recognizing members of our own species, although dog and cat owners will be ready to confirm that their pets look unique. Differences within species relate to characteristics such as size and shape but also to color: it is not only humans that show a wide range of skin pigmentation. Nevertheless, the cause of the variation in skin color in animals has remained largely a matter for conjecture....

Scientists Hope To Improve Genome-wide Association Studies With Two New Methods
2013-04-26 11:25:54

University of California - San Diego As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of. In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California,...

2013-03-18 11:08:57

A genetic score based on PCa risk-associated single nucleotide polymorphisms (SNPs) is an independent predictor of prostate biopsy outcomes, suggest the results of a new study conducted by a group from the Department of Urology Huashan Hospital, Fudan University in Shanghai, China. The authors, who relate their findings to the male population in China, also suggest that this score can improve predictive performance of existing clinical variables, especially for patients with a total PSA...

2013-02-07 15:01:03

Researchers led by biostatistician Andrea Foulkes have applied sophisticated statistical tools to existing large databases to reveal substantial new information about genes that cause such conditions as high cholesterol linked to heart disease Recently, large studies have identified some of the genetic basis for important common diseases such as heart disease and diabetes, but most of the genetic contribution to them remains undiscovered. Now researchers at the University of Massachusetts...

2012-11-07 11:49:14

Scientists have adopted a novel laboratory approach for determining the effect of genetic variation on the efficiency of the biological process that translates a gene's DNA sequence into a protein, such as hemoglobin, according to a presentation, Nov. 6, at the American Society of Human Genetics 2012 meeting in San Francisco. In the 0.1% of the DNA that differs between any two individuals, scientists search for the biological mechanisms underlying human genetic differences, including...

Genome Breakthrough Surpasses All DNA Barriers
2012-10-31 16:20:43

Lee Rannals for redOrbit.com - Your Universe Online A multinational team of scientists reports that they have successfully sequenced 1,092 human genomes from individuals across the globe. Their new study is the first to break the "1,000 genomes barrier." The researchers say the feat is a collegial effort to equip biologists and physicians with information that can be used to understand the normal range of human genetic variants so a patient's diseased genome can be interpreted in a...

2012-10-01 16:29:51

Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease. VWF (also known...

2012-09-12 13:15:45

In a recent study, investigators at Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) identified a gene linking age-related cataracts and Alzheimer's disease. The findings, published online in PLoS ONE, contribute to the growing body of evidence showing that these two diseases, both associated with increasing age, may share common etiologic factors. Gyungah Jun, PhD, from the departments of medicine, ophthalmology and biostatistics at BUSM and BUSPH, served as the...


Word of the Day
conjunto
  • A style of popular dance music originating along the border between Texas and Mexico, characterized by the use of accordion, drums, and 12-string bass guitar and traditionally based on polka, waltz, and bolero rhythms.
The word 'conjunto' comes through Spanish, from Latin coniūnctus, past participle of coniungere, to join together; see conjoin