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Last updated on April 18, 2014 at 6:20 EDT

Latest Single-nucleotide polymorphism Stories

2010-12-15 13:27:00

REYKJAVIK, Iceland, December 15, 2010 /PRNewswire-FirstCall/ -- Scientists from deCODE genetics and academic colleagues from Iceland, the UK, US, Netherlands, Spain and Romania today report the discovery of a set of single-letter variations in the sequence of the human genome (SNPs) that impact individual baseline levels of prostate specific antigen, or PSA. Testing for PSA levels is the most commonly used screening tool for the detection of prostate cancer. A prostate biopsy is routinely...

2010-12-03 22:43:28

Personalized medicine centers on being able to predict the risk of disease or response to a drug based on a person's genetic makeup. But a study by scientists at Washington University School of Medicine in St. Louis suggests that, for most common diseases, genes alone only tell part of the story. That's because the environment interacts with DNA in ways that are difficult to predict, even in simple organisms like single-celled yeast, their research shows. "The effects of a person's genes...

2010-11-19 13:32:52

Largest genetic study of the eating disorder detects common and rare variants Scientists at The Children's Hospital of Philadelphia have identified both common and rare gene variants associated with the eating disorder anorexia nervosa. In the largest genetic study of this psychiatric disorder, the researchers found intriguing clues to genes they are subjecting to further investigation, including genes active in neuronal signaling and in shaping interconnections among brain cells. Anorexia...

2010-11-11 11:00:00

Minor variations in the gene are associated with different sensitivity to acute and chronic pain BOSTON, Nov. 11, 2010 /PRNewswire-USNewswire/ -- While it has become clear in recent years that susceptibility to pain has a strong inherited component, very little is known about actual "pain genes" and how they work. In the November 12th issue of Cell, researchers at Children's Hospital Boston and their collaborators report on a novel human pain gene. People with minor variations in this...

2010-10-06 16:06:01

In an unprecedented international project, researchers have found multiple genetic mutations that play a role in heart attack or coronary artery disease (CAD) risk. The Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) "” published in Circulation: Cardiovascular Genetics, an American Heart Association journal "” consists of data from every published whole-genome study on genetic mutations in heart attack or CAD risk. Researchers are also pooling data...

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2010-10-06 09:11:39

Sensation seeking"”the urge to do exciting things"”has been linked to dopamine, a chemical that carries messages in your brain. For a new study published in Psychological Science, a journal of the Association for Psychological Science, scientists analyzed genes in the dopamine system and found a group of mutations that help predict whether someone is inclined toward sensation seeking. Sensation seeking has been linked to a range of behavior disorders, such as drug addiction. It...

2010-10-05 13:22:59

Radiation therapy is used to treat more than half of all cancer cases, but patient response to therapy can vary greatly. Genetics is increasingly being recognized as a significant contributor to inter-individual response to radiation, but the biology underlying response remains poorly understood. In a study published online today in Genome Research (www.genome.org), researchers employed a pharmacogenomics approach to find biomarkers associated with radiation response that could help to more...

2010-09-23 09:18:21

(Ivanhoe Newswire) -- Doctors cannot explain why one woman will develop ovarian cancer and another does not.  However, researchers have just identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. Spanning three continents and over 24,000 women, these findings have come from a large genome-wide associated study (GWAS) that has helped move researchers a major step closer to individualized risk assessment for ovarian...

2010-09-22 12:56:00

Spanish researchers have confirmed there is a genetic risk factor for osteoporosis and bone fractures. Although more studies are still needed, these findings will make it possible to take preventive measures. Scientists from the University of Barcelona (UB) have discovered that the genetic variant 677C>T (a single nucleotide polymorphism (SNP) that is very well known in genetic studies) is linked to osteoporotic vertebral fractures, which many women suffer from after the menopause. "In...

2010-09-20 18:50:44

Individuals with disrupting mutations in the BRCA1 gene are known to be at substantially increased risk of breast cancer throughout their lives. Now, discoveries from an international research team led by Mayo Clinic researchers show that some of those persons may possess additional genetic variants that modify their risk. These new findings enhancing individualized medicine appear in the current Nature Genetics. "These findings should be useful in helping determine individual risk for breast...