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Latest Single-nucleotide polymorphism Stories

2010-09-23 09:18:21

(Ivanhoe Newswire) -- Doctors cannot explain why one woman will develop ovarian cancer and another does not.  However, researchers have just identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. Spanning three continents and over 24,000 women, these findings have come from a large genome-wide associated study (GWAS) that has helped move researchers a major step closer to individualized risk assessment for ovarian...

2010-09-22 12:56:00

Spanish researchers have confirmed there is a genetic risk factor for osteoporosis and bone fractures. Although more studies are still needed, these findings will make it possible to take preventive measures. Scientists from the University of Barcelona (UB) have discovered that the genetic variant 677C>T (a single nucleotide polymorphism (SNP) that is very well known in genetic studies) is linked to osteoporotic vertebral fractures, which many women suffer from after the menopause. "In...

2010-09-20 18:50:44

Individuals with disrupting mutations in the BRCA1 gene are known to be at substantially increased risk of breast cancer throughout their lives. Now, discoveries from an international research team led by Mayo Clinic researchers show that some of those persons may possess additional genetic variants that modify their risk. These new findings enhancing individualized medicine appear in the current Nature Genetics. "These findings should be useful in helping determine individual risk for breast...

2010-09-20 18:49:19

International study locates key genetic variations A consortium of cancer researchers has identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. The findings appear in Nature Genetics in an article authored by a Mayo Clinic researcher. Researchers say that while more needs to be learned about the function of the specific chromosomal regions involved in susceptibility, the discoveries move them a major step closer to...

2010-09-20 18:46:39

An international consortium of scientists has discovered new genetic variants in five regions of the genome that affect the risk of ovarian cancer in the general population, according to two separate studies published today (Sunday), online in Nature Genetics. The consortium, including scientists from the U.S., Europe, Canada and Australia, based the new work on their earlier research comparing 10,283 women with ovarian cancer to 13,185 women without the disease. That effort had found a...

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2010-09-07 11:00:00

The first entire genome of an Irish individual has been sequenced. The sequence is reported in BioMed Central's open access journal, Genome Biology and provides insight into the evolutionary history of this distinct lineage. Led by Professor Brendan Loftus, the research team from UCD Conway Institute used data from a previous genotyping study to select a suitable Irish male representative for sequencing. Then, using pair- and single-ended Illumina short read sequencing, one of the next...

2010-09-01 20:42:36

HapMap 3 points the way forward for human genetics studies New findings show the value of genetic studies across human populations and the value of the latest DNA sequencing technologies to interrogate genetic variation. The results, from the latest phase of the international HapMap Project, are reported in Nature. The researchers' extensive study of genetic variation in multiple populations will form a framework for future genetic studies of variation and disease: their findings highlight...

2010-07-13 15:19:48

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. Although the Greek physician Hippocrates described Behcet's disease (pronounced BET'-chet's), more than 2,000 years ago, the condition existed in relative obscurity until the early 20th century. Named for the Turkish physician who first classified it in 1937, Behcet's disease is found almost...

2010-07-13 14:41:02

Genetic variant detected by genome-wide association found to increase expression of oncogene A genetic variant implicated in several cancers by genome-wide association studies (GWAS) has been found to drive increased expression of a known oncogene in the prostate. The study, published July 13th in Genome Research, showcases a new protocol for studying the activity of cancer-risk variants suggested by GWAS studies. The results also underscore the dramatic consequences of small genetic changes...

2010-07-12 05:45:00

REYKJAVIK, Iceland, July 12, 2010 /PRNewswire-FirstCall/ -- Points to Novel Pathway for Drug Discovery, Will be Incorporated Into Tests to Improve Screening and Early Detection of Abdominal Aortic Aneurysm, Heart Attack and PAD Scientists at deCODE genetics and academic colleagues from the Netherlands and twelve other countries across Europe and North America today report the discovery of a common single-letter variation (SNP) in the sequence of the human genome conferring risk of a...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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