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2011-12-21 14:18:57

A vicious circle that promotes cell proliferation Cancer cells are essentially immortal. The acquisition of an unlimited capacity to divide — the process of immortalization - is a central event in the genesis of tumors. Normally, cells are subject to stringent mechanisms which control their proliferation. Together these ensure that pre-malignant cells are induced to enter a senescent, non-dividing state or to undergo apoptosis, i.e. commit suicide. A research team led by Professor...

2011-12-19 11:43:13

Mutant huntingtin protein appears to block activity of Sirt1, suggesting potential treatment target Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital (MGH)-based research team reports that increased expression of Sirt1, one of a family of enzymes called...

Scientists Question Resveratrol Longevity Products
2011-09-22 10:14:07

   New research suggests that anti-ageing face creams and supplements, that actively use a 'miracle ingredient' commonly found in red wine, are a complete waste of time and money, and do nothing to improve your odds of living a longer life. Resveratrol, which is credited with many of the health benefits of red wine, has become a staple for several beauty companies and is used in numerous products that can fetch prices of up to several hundreds of dollars for just a small...

2011-01-13 16:12:22

Researchers from the Kimmel Cancer Center at Jefferson and two other institutions have discovered new evidence that suggests the "longevity" protein SIRT1, known for its life-spanning effects in different species, can inhibit the development of a known precursor to prostate cancer, prostatic intraepithelial neoplasia (PIN). Results from the study could lead to new cancer prevention drugs that could not only block prostate cancer but promote longevity. The study, published in the February 1...

2010-10-27 17:22:47

High doses or prolonged use of glucosamine causes the death of pancreatic cells and could increase the risk of developing diabetes, according to a team of researchers at Universit© Laval's Faculty of Pharmacy. Details of this discovery were recently published on the website of the Journal of Endocrinology. In vitro tests conducted by Professor Fr©d©ric Picard and his team revealed that glucosamine exposure causes a significant increase in mortality in insulin-producing...

2010-09-22 17:33:32

A new study uncovers a protein modification that may contribute to the formation of neuron-damaging neurofibrillary tangles in the human brain. The research, published by Cell Press in the September 23 issue of the journal Neuron, may lead to new strategies for treatment of neurodegenerative diseases that result from pathological aggregation of tau protein. Tau protein is common in the central nervous system where it helps to stabilize microtubules that form the neuronal cytoskeleton. Tau...

2010-09-22 14:38:49

Tau acetylation may contribute to Alzheimer's disease and other dementias Scientists at the Gladstone Institute of Neurological Disease (GIND) have uncovered new approaches to reduce toxic proteins in Alzheimer's disease (AD) and other neurodegenerative diseases. The results might lead to new treatments for these diseases. "We examined a protein called tau that has been strongly implicated in Alzheimer's disease," said Li Gan, PhD, senior author on the study. "Tau forms toxic protein...

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2010-07-29 10:00:00

Researchers watched two groups of mice, both nearing the end of a two-day fast. One group was quietly huddled together, but the other group was active and alert. The difference? The second set of mice had been engineered so their brains produced more SIRT1, a protein known to play a role in aging and longevity. "This result surprised us," says the study's senior author Shin-ichiro Imai, MD, PhD, an expert in aging research at Washington University School of Medicine in St. Louis. "It...

2010-07-22 15:29:29

SIRT1 gene appears to control production of the devastating protein fragments MIT biologists report that they have discovered the first link between the amyloid plaques that form in the brains of Alzheimer's patients and a gene previously implicated in the aging process, SIRT1. The researchers found that SIRT1 appears to control production of the devastating protein fragments, termed A-beta peptides, that make up amyloid plaques. They also showed that in mice engineered to develop Alzheimer's...

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2010-07-12 06:45:00

According to a study published on Sunday, a gene linked to increased life span through calorie restriction also appears to play a critical role in boosting memory and brain power. Laboratory experiments have proven that a protein encoded by the SIRT1 gene can help slow the aging process in rodents. According to the new findings, the enzyme, which is known as Sirtuin1 in humans, seems to enhance memory and nerve-cell development in the brain as well. The researchers wrote in the journal...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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