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Latest Sir2 Stories

2010-07-01 16:25:06

Better understanding of body's response to fasting may lead to therapies for metabolic disorders Massachusetts General Hospital (MGH) investigators have found that an enzyme with several important roles in energy metabolism also helps to turn off the body's generation of fats and cholesterol under conditions of fasting. The report in Genes & Development describes how SIRT1, one of a group of enzymes called sirtuins, suppresses the activity of a family of proteins called SREBPs, which...

2010-05-11 13:00:22

Apoptosis, the natural 'programmed' death of cells, is arrested in the aftermath of strenuous exercise. Researchers writing in the open access journal BMC Physiology studied peripheral blood mononuclear cells (PBMCs), isolated from whole blood samples taken from people after finishing a marathon, finding that the balance between expression of pro- and anti-apoptotic genes is shifted after the race. Gabriella Marfe from the University of Rome 'Tor Vergata' led a team of researchers who studied...

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2010-02-01 08:56:56

Understanding how aged and damaged mother cells manage to form new and undamaged daughter cells is one of the toughest riddles of ageing, but scientists now know how yeast cells do it. In a groundbreaking study researchers from the University of Gothenburg, Sweden, show how the daughter cell uses a mechanical "conveyor belt" to dump damaged proteins in the mother cell. "This ensures that the daughter cell is born without age-related damage," says professor Thomas Nyström from the...

2009-12-15 20:47:46

The Sirt1 enzyme in the body has generated enormous attention as a possible secret to living longer. Some scientists believe that fasting and drinking wine appear to aid in this quest because both likely activate Sirt1, unleashing its power. But researchers from Brown University, Rhode Island Hospital and the University of Texas Southwestern Medical Center have discovered that Sirt1 in the brain has its own potential health benefit: It may keep people thinner. They determined that inhibiting...

2009-12-15 12:52:26

A new paper from MIT biology professor Leonard Guarente strengthens the link between longevity proteins called sirtuins and the lifespan-extending effects of calorie restriction. For decades, it has been known that cutting normal calorie consumption by 30 to 40 percent can boost lifespan and improve overall health in animals such as worms and mice. Guarente believes that those effects are controlled by sirtuins "” proteins that keep cells alive and healthy in the face of stress by...

2009-06-10 14:31:19

Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level,...

2009-04-13 08:20:53

New study identifies another anti-cancer effect of the 'longevity' protein SIRT1 Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online April 13 and will appear in the April 20 print issue of the Journal of Cell Biology. The yeast and nematode equivalents of SIRT1 are fountains of youth that stretch lifespan. Whether SIRT1 slows aging in...

2009-02-20 10:02:32

People everywhere are feeling the stress of a worldwide recession. Our cells, too, are under continual assault from stress.Hidden from sight, our cells battle challenges such as their environment, bacteria, viruses, too much or too little oxygen, and physiological stressors. Molecular systems protect cells under assault, but those systems can break down, especially with age.To better understand how cells are protected from stress and damage, a team led by Northwestern University researchers...

2009-01-25 16:00:00

SAN DIMAS, Calif., Jan. 25 /PRNewswire/ -- A red wine resveratrol (rez-vair-ah-trawl) pill is edging closer to being confirmed as an anti-aging pill as researchers at LifeGen Technologies in Madison, Wisconsin, who were recently interviewed on CBS-TV's 60 MINUTES, reported this past September that Longevinex(R), a patent-applied-for nutriceutical matrix, activates 9-fold more longevity genes than plain resveratrol at a far lower dose than previously reported. (Photo:...

2008-11-06 00:00:04

A French study using mice suggests an experimental drug can protect against obesity and metabolic diseases associated with a high-fat diet. The study, published in the journal Cell Metabolism, suggests the synthetic SIRT1 activator -- called SRT1720 -- boosts metabolism, improves glucose tolerance and insulin sensitivity, and enhances exercise endurance. The new chemical entity was used by researchers to activate the SIRT1 gene pathway in mice, boosting their metabolic levels. "These...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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