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2008-11-05 15:35:00

Researchers in France say they have found a drug that tricks the body into burning off fat even when on a high-fat diet. The drug SRT1720 "” a chemical cousin of red wine extract resveratrol "” targets the protein SIRT1, and is thought to combat ageing. The drug protected mice against weight gain and insulin resistance, according to the team from the University of Louis Pasteur. Although new drug treatments are needed, they should be used alongside lifestyle changes, UK obesity...

2008-10-01 09:00:12

CAMBRIDGE, Mass., Oct. 1 /PRNewswire/ -- Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers to better develop novel therapeutics and molecular diagnostics, today announced the publication of a paper authored by Gil Blander, Ph.D. et al, titled "SIRT1 Promotes Differentiation of Normal Human Keratinocytes" in the Journal of Investigative Dermatology. This research, led by Genstruct scientists and supported in part through an Estee...

2008-10-01 09:00:09

Sirtris, a GSK company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced today that it published a new review article on the growing body of sirtuin research and its potential to treat diseases of aging such as Type 2 Diabetes, mitochondrial disorders, inflammation, cancer, and heart disease. Entitled "SIRTUINS - Novel Therapeutic Targets to Treat Age-Associated Diseases," the review appears in today's issue of the journal...

2008-09-17 12:00:35

Sirtris, a GlaxoSmithKline company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 diabetes, has completed an agreement with Harvard University to exclusively license two patent applications covering SIRT3-based methods of treatments and assays. Sirtuins are a family of enzymes which regulate the aging process and have been the subject of extensive research. While SIRT1 - the founding member of this class of enzymes - is currently the...

2008-09-16 09:00:15

Sirtris, a GSK Company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced today that it has completed an agreement with Harvard University to exclusively license two patent applications covering SIRT3-based methods of treatments and assays. Sirtuins are a family of enzymes which regulate the aging process and have been the subject of extensive research. While SIRT1 -- the founding member of this class of enzymes -- is...

2008-09-10 06:00:08

SAN DIMAS, Calif., Sept. 10 /PRNewswire/ -- While the red wine molecule resveratrol (rez-vair-ah-trawl) has recently attracted scientific and public attention as a longevity molecule that allegedly mimics the effects of a calorie-restricted diet, the science surrounding this molecule has taken a dramatic turn in recent months, according to Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), a major brand resveratrol supplement. (Photo:...

2008-08-28 03:00:22

By Saey, Tina Hesman Work could lead to drugs for obesity, aging and jet lag Cue stomach rumbles SIRT1 sets internal clock To metabolism Timing is everything, especially when it comes to basic biological functions such as eating, sleeping and liver activity. Scientists have known for ages that metabolism is tied to the body's daily rhythms but have not known how. Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that links metabolism to the...

2008-07-01 09:00:13

Elixir Pharmaceuticals, Inc., today announced the Company has entered an exclusive license agreement with Boston University to key intellectual property covering discoveries regarding the use of modulators of SIRT1, a member of the sirtuin class of protein deacetylase enzymes. SIRT1 is the human equivalent of Sir2, a gene identified in yeast that has been recognized to play a key role in the control of lifespan, metabolism, resistance to stress and other cellular regulatory pathways. The...

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2008-01-24 10:10:00

Researchers studying antioxidants to reverse lung damage A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging. Without this gene we not only lose a bit of youthfulness "“ but the lungs are left open to destructive inflammation and diseases such as chronic obstructive pulmonary disease (COPD) and lung cancer. By identifying the Sirtuin (SIRT1) gene's role...

2006-06-16 08:44:36

By Amanda Beck WASHINGTON (Reuters) - Eating fewer calories may help prevent the symptoms of Alzheimer's disease, researchers reported on Friday. A study in mice suggests a lower-calorie diet can help trigger the production of a protein that protects the brain from the disease, said researchers at the Mount Sinai School of Medicine in New York City. In the study, the mice in one group were permitted to eat as they wished, while the other group of mice was fed only 70 percent of...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'