Latest Sirolimus Stories

2012-06-01 09:27:49

New study creates cells that act like circuits, a step toward developing cellular computers Johns Hopkins scientists have engineered cells that behave like AND and OR Boolean logic gates, producing an output based on one or more unique inputs. This feat, published in the May issue of Nature Chemical Biology, could eventually help researchers create computers that use cells as tiny circuits. Study leader Takanari Inoue, Ph.D., an assistant professor in the Department of Cell Biology and...

2012-05-17 09:28:23

A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive Cancer Center researchers conducting the study in cancer patients whose tumors have resisted multiple treatments say the combination demonstrates "promising evidence" of disease control and should be studied in a phase II trial. Their clinical findings and additional data...

2012-05-02 15:07:00

IDIBELL researchers discover that combining two mTOR inhibitors cause the regression of hepatocellular carcinoma The combination of two inhibitors of protein mTOR stops the growth of primary liver cancer and destroys tumor cells, according to a study by researchers of the Group of Metabolism and Cancer at Bellvitge Biomedical Research Institute (IDIBELL). The study results are been published on the online edition of the journal Science Translational Medicine. Primary liver cancer or...

2012-05-01 21:18:47

Scientists at Joslin Diabetes Center have identified a key mechanism of action for the TOR (target of rapamycin) protein kinase, a critical regulator of cell growth which plays a major role in illness and aging. This finding not only illuminates the physiology of aging but could lead to new treatments to increase lifespan and control age-related conditions, such as cancer, type 2 diabetes, and neurodegeneration. Over the past decade, studies have shown that inhibiting TOR activity, which...

Study Reveals Why Rapamycin Causes Diabetes-like Symptoms
2012-04-04 11:01:49

Rapamycin is an immunosuppressant derived from bacteria found on Easter Island. It was approved for organ transplant patients by the FDA in 1999. The drug helps to prevent organ rejection and is currently undergoing clinical trials as a cancer treatment. It shows promise for its anti-cancer activity and may even slow the aging process. Pere Puigserver of Dana-Farber Cancer Institute says, “This is a drug that is pretty well known for its benefits. Rapamycin is one of the few drugs,...

2012-04-02 15:53:36

Aberrations in translation regulators associated with hormone receptor-positive disease survival Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. All of the aberrantly activated translational proteins are regulated by the PI3K/mTOR molecular signaling pathway, which has been implicated in...

Word of the Day
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.