Latest SIRT3 Stories
Most people appreciate that not getting enough sleep impairs cognitive performance. For the chronically sleep-deprived such as shift workers, students, or truckers, a common strategy is simply to catch up on missed slumber on the weekends.
The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation.
In efforts to understand what influences life span, cancer and aging, scientists are building roadmaps to navigate and learn about cells at the molecular level.
Research published in the Cancer Cell journal in March was a significant step in knowing the causes of cancer better, especially breast cancer, revealing that the lack or loss of a protein in the cells known as SIRT3, induces the proliferation of this disease and thereby, this protein can be an may be a therapeutic target in the development of effective therapies for cancer.
The most common type of breast cancer in older women â€” estrogen and progesterone receptor (ER/PR) positive breast cancer â€” has been linked to a protein that fends off aging-related cellular damage.
For decades, scientists have been searching for the fundamental biological secrets of how eating less extends lifespan.
With obesity and obesity-related diseases epidemic in the developed world, a clear understanding of how metabolism is regulated is crucial.
Sirtuin proteins have been shown to promote longevity in many organisms, and increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan.
Sirtris, a GlaxoSmithKline company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 diabetes, has completed an agreement with Harvard University to exclusively license two patent applications covering SIRT3-based methods of treatments and assays.