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Latest Sirtuin 1 Stories

Human Genetic Mutation Discovery Could Lead To New Treatments For Type 1 Diabetes
2013-03-05 12:58:58

Cell Press In type 1 diabetes, the immune system destroys insulin-producing cells in the pancreas, but the precise cause has not been clear. A study published by Cell Press on March 5th in Cell Metabolism reveals that a single mutation in the "longevity gene" SIRT1 can cause type 1 diabetes in humans. The findings unearth the role this gene plays in human autoimmunity and disease and also offer new avenues for treating a range of autoimmune disorders. "We describe one of the first...

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2010-07-29 10:00:00

Researchers watched two groups of mice, both nearing the end of a two-day fast. One group was quietly huddled together, but the other group was active and alert. The difference? The second set of mice had been engineered so their brains produced more SIRT1, a protein known to play a role in aging and longevity. "This result surprised us," says the study's senior author Shin-ichiro Imai, MD, PhD, an expert in aging research at Washington University School of Medicine in St. Louis. "It...

2009-12-15 20:47:46

The Sirt1 enzyme in the body has generated enormous attention as a possible secret to living longer. Some scientists believe that fasting and drinking wine appear to aid in this quest because both likely activate Sirt1, unleashing its power. But researchers from Brown University, Rhode Island Hospital and the University of Texas Southwestern Medical Center have discovered that Sirt1 in the brain has its own potential health benefit: It may keep people thinner. They determined that inhibiting...

2009-04-13 08:20:53

New study identifies another anti-cancer effect of the 'longevity' protein SIRT1 Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online April 13 and will appear in the April 20 print issue of the Journal of Cell Biology. The yeast and nematode equivalents of SIRT1 are fountains of youth that stretch lifespan. Whether SIRT1 slows aging in...

2008-11-06 00:00:04

A French study using mice suggests an experimental drug can protect against obesity and metabolic diseases associated with a high-fat diet. The study, published in the journal Cell Metabolism, suggests the synthetic SIRT1 activator -- called SRT1720 -- boosts metabolism, improves glucose tolerance and insulin sensitivity, and enhances exercise endurance. The new chemical entity was used by researchers to activate the SIRT1 gene pathway in mice, boosting their metabolic levels. "These...

2005-08-17 14:20:11

Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. Their study will appear in the August 17 issue of Cell Metabolism. According to senior author Shin-ichiro Imai, M.D., the finding suggests that therapies that increase the activity of Sirt1 could be of benefit in type 2...

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2005-07-19 14:55:00

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide. The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations. The researchers said the gene, known as SIRT1, suppresses longevity, and may play a role in regulating the aging process. But they caution against interpreting the results too broadly, because dividing mouse cells in culture are an imperfect model of...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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