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Latest Sirtuin activating compound Stories

2013-03-08 12:12:24

Findings identify universal mechanism for activating anti-aging pathway A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. What's more, the researchers have uncovered the molecular mechanism for this interaction, and show that a class of more potent drugs currently in clinical trials act in a similar fashion. Pharmaceutical compounds similar to...

2010-07-22 15:29:29

SIRT1 gene appears to control production of the devastating protein fragments MIT biologists report that they have discovered the first link between the amyloid plaques that form in the brains of Alzheimer's patients and a gene previously implicated in the aging process, SIRT1. The researchers found that SIRT1 appears to control production of the devastating protein fragments, termed A-beta peptides, that make up amyloid plaques. They also showed that in mice engineered to develop Alzheimer's...

2009-12-15 12:52:26

A new paper from MIT biology professor Leonard Guarente strengthens the link between longevity proteins called sirtuins and the lifespan-extending effects of calorie restriction. For decades, it has been known that cutting normal calorie consumption by 30 to 40 percent can boost lifespan and improve overall health in animals such as worms and mice. Guarente believes that those effects are controlled by sirtuins "” proteins that keep cells alive and healthy in the face of stress by...

2008-11-28 07:54:01

Harvard researchers report finding a new clue into the reason for aging in a minor ingredient of red wine and its role in activating a protein. Scientists said they made their finding while trying to understand how the agent resveratrol improves the health and lifespan of laboratory mice, The New York Times reported. In their finding, published online in the journal Cell, a group led by David Sinclair of the Harvard Medical School said it was believed that the integrity of chromosomes is...

2008-11-06 00:00:04

A French study using mice suggests an experimental drug can protect against obesity and metabolic diseases associated with a high-fat diet. The study, published in the journal Cell Metabolism, suggests the synthetic SIRT1 activator -- called SRT1720 -- boosts metabolism, improves glucose tolerance and insulin sensitivity, and enhances exercise endurance. The new chemical entity was used by researchers to activate the SIRT1 gene pathway in mice, boosting their metabolic levels. "These...

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2008-11-05 15:35:00

Researchers in France say they have found a drug that tricks the body into burning off fat even when on a high-fat diet. The drug SRT1720 "” a chemical cousin of red wine extract resveratrol "” targets the protein SIRT1, and is thought to combat ageing. The drug protected mice against weight gain and insulin resistance, according to the team from the University of Louis Pasteur. Although new drug treatments are needed, they should be used alongside lifestyle changes, UK obesity...

2008-10-17 09:00:27

Sirtris, a GSK company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, today announced that it will provide an update on the Company's clinical and preclinical progress at the 2008 Boston Biotech R&D Conference on Wednesday, October 22, 2008 at Harvard Medical School. Christoph Westphal, M.D., Ph.D., Chief Executive Officer of Sirtris, a GSK company, will provide an update on the Company's lead new chemical entity (NCE)...

2008-09-17 03:00:10

By Kent, David M IN MY CAMBRIDGE, Massachusetts, neighborhood, competing restaurants have promoted opposing gastronomic and life strategies. The motto at Jae's, a "nouvelle" Pan-Asian cafe specializing in presenting small, stylized foods on oversized white plates, was "Eat at Jae's. Live forever!" The sign next door at Jake and Earl's take- out grill read "Eat BBQ. Die Happy!" Although neither establishment survived long, the stark choice that together they presented- between a savory,...

2007-08-16 09:18:10

Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that Sirtris, together with leading sirtuin researchers David A Sinclair, Ph.D. and Leonard P. Guarente, Ph.D., published a review in the MIT Tech Review entitled "Developing Drugs to Treat Diseases of Aging." The review highlights the discovery of sirtuins, a novel class of enzymes, and their role in the aging...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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