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Latest Sirtuin Stories

2011-12-23 06:48:49

(Ivanhoe Newswire) — Treatment that increases brain levels of a crucial regulatory enzyme may slow the loss of brain cells that characterize Huntington´s disease (HD) and other neurodegenerative disorders, according to this study. Increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect. "Diseases such as Huntington's,...

Eating Less Improves Brain Function
2011-12-20 08:36:55

Calorie restriction activates genes linked to longevity and brain function, according to a new Italian study with mice. The researchers found that overeating may cause brain aging, while eating less turns on a molecule that helps the brain stay young. The discovery could lead to new treatments to keep the brain in a healthy, youthful state without the need for a restrictive diet, the researchers said. Previous studies using animals have found that low calorie diets extend life,...

Scientists Question Resveratrol Longevity Products
2011-09-22 10:14:07

   New research suggests that anti-ageing face creams and supplements, that actively use a 'miracle ingredient' commonly found in red wine, are a complete waste of time and money, and do nothing to improve your odds of living a longer life. Resveratrol, which is credited with many of the health benefits of red wine, has become a staple for several beauty companies and is used in numerous products that can fetch prices of up to several hundreds of dollars for just a small...

2011-04-05 15:53:56

Research published in the Cancer Cell journal in March was a significant step in knowing the causes of cancer better, especially breast cancer, revealing that the lack or loss of a protein in the cells known as SIRT3, induces the proliferation of this disease and thereby, this protein can be an may be a therapeutic target in the development of effective therapies for cancer. The research was led by Dra. Marcia Haigis of the Harvard Medical School, with the participation of Dr. Arkaitz...

2011-01-28 00:16:42

The most common type of breast cancer in older women "” estrogen and progesterone receptor (ER/PR) positive breast cancer "” has been linked to a protein that fends off aging-related cellular damage. A new study led by Vanderbilt-Ingram Cancer Center researcher David Gius, M.D., Ph.D., now shows how a deficiency in this aging-associated protein may set the stage for these tumors to develop. The findings, published in Molecular Cell, provide information that could assist in the...

2010-11-18 16:46:04

For decades, scientists have been searching for the fundamental biological secrets of how eating less extends lifespan. It has been well documented in species ranging from spiders to monkeys that a diet with consistently fewer calories can dramatically slow the process of aging and improve health in old age. But how a reduced diet acts at the most basic level to influence metabolism and physiology to blunt the age-related decline of tissues and cells has remained, for the most part, a...

2010-07-22 15:29:29

SIRT1 gene appears to control production of the devastating protein fragments MIT biologists report that they have discovered the first link between the amyloid plaques that form in the brains of Alzheimer's patients and a gene previously implicated in the aging process, SIRT1. The researchers found that SIRT1 appears to control production of the devastating protein fragments, termed A-beta peptides, that make up amyloid plaques. They also showed that in mice engineered to develop Alzheimer's...

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2010-07-12 06:45:00

According to a study published on Sunday, a gene linked to increased life span through calorie restriction also appears to play a critical role in boosting memory and brain power. Laboratory experiments have proven that a protein encoded by the SIRT1 gene can help slow the aging process in rodents. According to the new findings, the enzyme, which is known as Sirtuin1 in humans, seems to enhance memory and nerve-cell development in the brain as well. The researchers wrote in the journal...

2010-07-01 16:25:06

Better understanding of body's response to fasting may lead to therapies for metabolic disorders Massachusetts General Hospital (MGH) investigators have found that an enzyme with several important roles in energy metabolism also helps to turn off the body's generation of fats and cholesterol under conditions of fasting. The report in Genes & Development describes how SIRT1, one of a group of enzymes called sirtuins, suppresses the activity of a family of proteins called SREBPs, which...

2010-05-11 13:00:22

Apoptosis, the natural 'programmed' death of cells, is arrested in the aftermath of strenuous exercise. Researchers writing in the open access journal BMC Physiology studied peripheral blood mononuclear cells (PBMCs), isolated from whole blood samples taken from people after finishing a marathon, finding that the balance between expression of pro- and anti-apoptotic genes is shifted after the race. Gabriella Marfe from the University of Rome 'Tor Vergata' led a team of researchers who studied...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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