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Latest Sirtuin Stories

2010-04-29 07:59:00

VIENNA, April 29, 2010 /PRNewswire/ -- Can Resveratrol, the so-called miracle molecule found in red wine, peanuts and an obnoxious plant called Chinese Giant Knotweed, actually improve your brain function? Scientists at Northumbria University in the UK have just published a double-blind, peer-reviewed study in the journal, American Journal of Clinical Nutrition, which concludes that a relatively modest dose of this compound in the form of one or two capsules may just do that. In...

2009-12-15 12:52:26

A new paper from MIT biology professor Leonard Guarente strengthens the link between longevity proteins called sirtuins and the lifespan-extending effects of calorie restriction. For decades, it has been known that cutting normal calorie consumption by 30 to 40 percent can boost lifespan and improve overall health in animals such as worms and mice. Guarente believes that those effects are controlled by sirtuins "” proteins that keep cells alive and healthy in the face of stress by...

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2009-10-15 07:55:00

A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet. The findings from a new UT Southwestern Medical Center study suggest that when acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes. Prior research has shown that the compound exerts anti-diabetic actions when given orally to animals...

2009-10-06 11:43:04

Resveratrol, a molecule found in red grapes, has been shown to improve diabetes when delivered orally to rodents. Until now, however, little has been known about how these beneficial changes are mediated in the body. A new study accepted for publication in Endocrinology, a journal of The Endocrine Society, shows that the brain plays a key role in mediating resveratrol's anti-diabetic actions, potentially paving the way for future orally-delivered diabetes medications that target the brain....

2009-08-03 19:20:00

Sirtuin proteins have been shown to promote longevity in many organisms, and increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan. New data, generated in mice, by Mahesh Gupta and colleagues, at the University of Chicago, Chicago, has revealed that Sirt3 helps protect the mouse heart.In the study, the heart of mice lacking Sirt3 was found to show signs of becoming enlarged (a process known as cardiac hypertrophy), at about 8 weeks of age. Further,...

2009-07-09 15:08:00

FT. LEE, N.J., July 9 /PRNewswire/ -- Red wine (resveratrol) pills appear to be the rage these days and a local group of cardiologists wants to lead the way for patients and consumers to learn more about them. They may be among the first U.S. cardiologists to do so. (Photo: http://www.newscom.com/cgi-bin/prnh/20090709/LA44390) In response to growing inquiries about the heart-healthy properties of red wine pills, a local cardiology group says it will soon begin to study the effects of these...

2009-06-11 15:42:10

Resveratrol shows therapeutic potential for cancer chemoprevention as well as cardioprotection. Resveratrol may aid in the prevention of age-related disorders, such as neurodegenerative diseases, inflammation, diabetes, and cardiovascular disease. Low doses of resveratrol improve cell survival as a component of cardio- and neuro-protection, while high doses increase cell death.   The benefits of alcohol are all about moderation. Low to moderate drinking "“ especially of red...

2009-06-10 14:31:19

Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level,...

2009-05-18 23:52:55

U.S. researchers have found cocaine regulated molecular pathways that may lead to addiction treatments. The study, published in Cell Press, finds long-lasting changes in behavior are elicited as cocaine regulates gene expression in a crucial reward region of the brain. Although we have known for some time that changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry that is seen during drug addiction, how those specific genes are regulated is not...

2009-05-13 15:09:47

New research sheds light on how cocaine regulates gene expression in a crucial reward region of the brain to elicit long-lasting changes in behavior. The study, published by Cell Press in the May 14th issue of the journal Neuron, provides exciting insight into the molecular pathways regulated by cocaine and may lead to new strategies for battling drug addiction. It is well established that addictive drugs induce persistent changes in the brain's reward circuits. Previous research has...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.