Latest Sirtuin Stories

2008-09-16 09:00:15

Sirtris, a GSK Company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced today that it has completed an agreement with Harvard University to exclusively license two patent applications covering SIRT3-based methods of treatments and assays. Sirtuins are a family of enzymes which regulate the aging process and have been the subject of extensive research. While SIRT1 -- the founding member of this class of enzymes -- is...

2008-09-10 06:00:08

SAN DIMAS, Calif., Sept. 10 /PRNewswire/ -- While the red wine molecule resveratrol (rez-vair-ah-trawl) has recently attracted scientific and public attention as a longevity molecule that allegedly mimics the effects of a calorie-restricted diet, the science surrounding this molecule has taken a dramatic turn in recent months, according to Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), a major brand resveratrol supplement. (Photo:...

2008-08-28 03:00:22

By Saey, Tina Hesman Work could lead to drugs for obesity, aging and jet lag Cue stomach rumbles SIRT1 sets internal clock To metabolism Timing is everything, especially when it comes to basic biological functions such as eating, sleeping and liver activity. Scientists have known for ages that metabolism is tied to the body's daily rhythms but have not known how. Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that links metabolism to the...

2008-07-01 09:00:13

Elixir Pharmaceuticals, Inc., today announced the Company has entered an exclusive license agreement with Boston University to key intellectual property covering discoveries regarding the use of modulators of SIRT1, a member of the sirtuin class of protein deacetylase enzymes. SIRT1 is the human equivalent of Sir2, a gene identified in yeast that has been recognized to play a key role in the control of lifespan, metabolism, resistance to stress and other cellular regulatory pathways. The...

2008-01-24 10:10:00

Researchers studying antioxidants to reverse lung damage A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging. Without this gene we not only lose a bit of youthfulness "“ but the lungs are left open to destructive inflammation and diseases such as chronic obstructive pulmonary disease (COPD) and lung cancer. By identifying the Sirtuin (SIRT1) gene's role...

2007-08-16 09:18:10

Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that Sirtris, together with leading sirtuin researchers David A Sinclair, Ph.D. and Leonard P. Guarente, Ph.D., published a review in the MIT Tech Review entitled "Developing Drugs to Treat Diseases of Aging." The review highlights the discovery of sirtuins, a novel class of enzymes, and their role in the aging...

2005-08-17 14:20:11

Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. Their study will appear in the August 17 issue of Cell Metabolism. According to senior author Shin-ichiro Imai, M.D., the finding suggests that therapies that increase the activity of Sirt1 could be of benefit in type 2...

2005-07-28 14:36:39

BOSTON "“ Mice, rats, worms, flies, and yeast all live longer on a low-calorie diet, which also seems to protect mammals against cancer and other aging-related diseases. A gene called SIR2 is thought to control this process. Now, researchers at Harvard Medical School and UC Davis have discovered four cousins of the SIR2 gene that also extend lifespan, suggesting that the whole family of SIR2 genes is involved in controlling lifespan. The research indicates potential targets for...

Word of the Day
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'