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Latest Skeletal muscle Stories

2012-02-15 10:59:42

The proteins actin, myosin and titin are big players in the business of muscle contraction. Scientists at the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now examined another muscle protein — myomesin — which they discovered can stretch up to two-and-a-half times its length, unfolding in a way that was previously unknown. The study is published 14 February in the open-access, online journal PLoS Biology. Myomesin links muscle filaments, which stretch...

Muscle Stem Cells Activated By Exercise
2012-02-07 05:19:26

University of Illinois researchers determined that an adult stem cell present in muscle is responsive to exercise, a discovery that may provide a link between exercise and muscle health. The findings could lead to new therapeutic techniques using these cells to rehabilitate injured muscle and prevent or restore muscle loss with age. Mesenchymal stem cells (MSCs) in skeletal muscle have been known to be important for muscle repair in response to non-physiological injury, predominantly in...

2012-01-30 12:36:51

A new study in the Journal of General Physiology (www.jgp.org) uses state-of-the-art fluorescence microscopy to provide a striking 3-D picture of how class V myosins (myoV) "walk" along their actin track. The myosin superfamily of mechanoenzymes, more commonly referred to as molecular motors, play an important role in muscle contraction and other basic cellular processes. MyoV, one of the most highly studied molecular motors, has the ability to travel long distances by taking multiple...

2012-01-24 11:00:15

Simon Fraser University associate professor James Wakeling is adding to the arsenal of increasingly sophisticated medical imaging tools with a new signal-processing method for viewing muscle activation details that have never been seen before. Fascinated with the mechanics of muscle movement in people and animals, Wakeling has developed a novel method using ultrasound imaging, 3D motion-capture technology and proprietary data-processing software to scan and capture 3D maps of the muscle...

2012-01-23 13:29:45

Research team with RUB involvement reports in Genes and Development The same mechanism that stabilizes the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute of Physiology) in cooperation with American and German colleagues. An enzyme attaches a methyl group to the protein Hsp90, which then forms a complex with the muscle protein titin. When the...

2012-01-03 14:06:30

We take it for granted, but the fact that our muscles grow when we work them makes them rather unique. Now, researchers have identified a key ingredient needed for that bulking up to take place. A factor produced in working muscle fibers apparently tells surrounding muscle stem cell "higher ups" that it's time to multiply and join in, according to a study in the January Cell Metabolism, a Cell Press journal. In other words, that so-called serum response factor (Srf) translates the...

2011-12-21 13:07:40

New research hopes to explain premature births and failed inductions of labor. The study by academics at the University of Bristol suggests a new mechanism by which the level of myosin phosphorylation is regulated in the pregnant uterus. The researchers, Dr Claire Hudson and Professor Andrés López Bernal in the School of Clinical Sciences and Dr Kate Heesom in the University Proteomics Facility and the School of Biochemistry, have discovered that phosphorylation...

2011-12-14 11:49:04

Jamb and Jamc are essential proteins for the fusion of muscle cells Researchers at the Wellcome Trust Sanger Institute have discovered two proteins that are essential for the fusion of muscle cells to build muscle fibers. Their discovery might help us better understand and treat illnesses such as muscle-wasting disorders and diseases of bone over-growth, in which cellular fusion is an important feature. Cellular fusion is necessary to form larger cells that have specific functions...

2011-12-02 02:05:00

Discovery could help future treatments for muscle repairs, disorders When a muscle is damaged, dormant adult stem cells called satellite cells are signaled to “wake up” and contribute to repairing the muscle. University of Missouri researchers recently found how even distant satellite cells could help with the repair, and are now learning how the stem cells travel within the tissue. This knowledge could ultimately help doctors more effectively treat muscle disorders such as...

2011-12-01 13:35:29

Mouse model shows that generating energy from sugar leads to fitter muscles and increased athletic ability Muscle performance and fitness are partly determined by how well your muscle cells use sugar as a fuel source. In turn, exercising improves the muscle's ability to take up sugars from the bloodstream and burn them for energy. On the flip side, conditions that reduce physical activity -- such as obesity or chronic disease -- reduce the muscle's capacity to burn sugar. A new study by...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.