Latest Small molecule Stories
New molecule neutralizes key protein, once thought to be 'undruggable,' with roles in leukemia and other cancers.
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin.
HEIDELBERG, Germany, September 16 /PRNewswire/ -- - Integrated Chemical Genetics and Proteomics Approach Identifies new Potential Drug Targets in Wnt Pathway Cellzome announces today, the publication entitled "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling"** is now available online in Nature. The paper describes how Cellzome's quantitative chemical proteomics platform was used to identify a small molecule which plays a critical role in the regulation of...
Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity.
Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes.
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists funded by the Biotechnology and Biological Sciences Research Council have harnessed a new drug discovery tool to identify a new player in the body's insulin secretion process. This finding could spark a completely new class of drugs to treat type 2 diabetes.
Addex Pharmaceuticals (SWISS: ADXN) announced today that on September 25, 2008, S.R.
U.S. scientists have created a computerized method of analyzing cellular activity that correctly predicts the anti-tumor activity of several molecules.
Imagine having one polymer and one small molecule that instantly assemble into a flexible but strong sac in which you can grow human stem cells, creating a sort of miniature laboratory. And that sac, if used for cell therapy, could cloak the stem cells from the human bodyâ€™s immune system and biodegrade upon arriving at its destination, releasing the stem cells to do their work.
- An uxorious, effeminate, or spiritless man.
- A timorous, cowardly fellow.