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Latest Small molecule Stories

2009-11-11 17:57:48

New molecule neutralizes key protein, once thought to be 'undruggable,' with roles in leukemia and other cancers Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed. Their discovery, published in the November 12 issue of Nature, lays the foundation for a new kind of therapy aimed directly at a critical human protein "” one of a few thousand so-called transcription...

2009-11-03 16:04:28

Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. The research, published Oct. 23 in the journal Science, could potentially lead to the development of other compounds with similarly beneficial effects. The lovastatin-synthesizing enzyme is one of the most interesting but least understood of the...

2009-09-16 13:04:00

HEIDELBERG, Germany, September 16 /PRNewswire/ -- - Integrated Chemical Genetics and Proteomics Approach Identifies new Potential Drug Targets in Wnt Pathway Cellzome announces today, the publication entitled "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling"** is now available online in Nature. The paper describes how Cellzome's quantitative chemical proteomics platform was used to identify a small molecule which plays a critical role in the regulation...

2009-08-19 12:38:33

Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also allows the small molecules that are attracted to a given protein to select the structure that permits the best binding. That premise could help in drug discovery and in designing compounds that will have the most impact on protein function to better treat a host of...

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2009-08-18 12:45:00

Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes. Biochemists at the Technische Universitaet Muenchen (TUM) have illuminated a reaction pathway that does just that, in collaboration with researchers from Nereus Pharmaceuticals, based in San Diego, California. In the current issue of the Journal of Medicinal Chemistry,...

2009-06-03 14:22:13

In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.Scientists at the University of Michigan and the University of California at Berkeley have taken a step forward on that route by developing small molecules that mimic the behavior and function of a much larger and more complicated natural...

2009-02-23 09:21:13

Scientists funded by the Biotechnology and Biological Sciences Research Council have harnessed a new drug discovery tool to identify a new player in the body's insulin secretion process. This finding could spark a completely new class of drugs to treat type 2 diabetes. In work published today (22 February) in Nature Chemical Biology researchers at the University of Oxford explain how they have exploited new technology to create a cheap and efficient method of drug discovery that will allow...

2008-09-26 12:00:35

Addex Pharmaceuticals (SWISS: ADXN) announced today that on September 25, 2008, S.R. One Ltd, the investment arm of GlaxoSmithKline plc, has informed of reaching the threshold of 3.0% in the shareholding of Addex Pharmaceuticals Ltd., holding a total of 175,951 registered shares, corresponding to 3.0% of the voting rights. About Addex Addex Pharmaceuticals discovers and develops allosteric modulators for human health. Allosteric modulators are an emerging class of orally available small...

2008-06-17 12:00:12

U.S. scientists have created a computerized method of analyzing cellular activity that correctly predicts the anti-tumor activity of several molecules. Researchers Jeffrey Skolnick and John McDonald led a Georgia Institute of Technology team in developing the tool, called CoMet, that studies the integrated machinery of the cell, predicting which components can have an effect on cancer. This opens up the possibility of novel therapeutics for cancer and develops our understanding of why...

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2008-03-27 14:40:01

Imagine having one polymer and one small molecule that instantly assemble into a flexible but strong sac in which you can grow human stem cells, creating a sort of miniature laboratory. And that sac, if used for cell therapy, could cloak the stem cells from the human body's immune system and biodegrade upon arriving at its destination, releasing the stem cells to do their work.Futuristic? Only in part. A research team from Northwestern University's Institute for BioNanotechnology in Medicine...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.