Latest SOD1 Stories
Researchers from Northwestern University Feinberg School of Medicine have discovered a link between sporadic and familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease also known as Lou Gehrig's disease.
CARLSBAD, Calif., March 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that it has initiated a Phase 1 study of ISIS-SOD1Rx in patients with an inherited, aggressive form of Lou Gehrig's disease also known as familial amyotrophic lateral sclerosis (ALS).
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease that causes progressive weakness, disability, and death. Treatments are largely palliative.
A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, in mice.
A new mouse model of amyotrophic lateral sclerosis (ALS) closely resembles humans with the paralyzing disorder, researchers at Washington University School of Medicine in St. Louis report.
Researchers at the University of Texas have identified an abnormality in molecules they believe is responsible for one form of Lou Gehrig's disease. The molecules, known as immature superoxide dismutase 1 or SOD1, can't interact normally with metals that provide stability and instead become destructive knots that are seen in one inherited form of amyotrophic lateral sclerosis, the formal name of Lou Gehrig's disease, the University of Texas Health Science Center at San Antonio reports. The...
An international consortium of scientists supported by the ALS Association has identified a new gene that may be responsible for about five percent of all inherited cases of amyotrophic lateral sclerosis (ALS), a progressive disease affecting nerve cells in the brain and spinal cord.
An incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs. Researchers from the University of Missouri and the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic lateral sclerosis (ALS), the human disease also known as Lou Gehrig's Disease.
A new study indicates that mutant Cu/Zn superoxide dismutase (SOD1) enzymes that are associated with an inherited form of Lou Gehrig's disease cause the protein to become sticky in tissues. Partial unfolding of the mutant protein can expose hydrophobic residues that may promote abnormal interactions with other proteins or membranes in the cell.
- A transitional zone between two communities containing the characteristic species of each.