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Latest SOD1 Stories

2010-05-06 13:32:16

Finding could ultimately lead to therapy for ALS Researchers from Northwestern University Feinberg School of Medicine have discovered a link between sporadic and familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease also known as Lou Gehrig's disease. Researchers found that a protein called FUS forms characteristic skein-like cytoplasmic inclusions in spinal motor neurons in most cases of ALS. Mutations in this gene have been previously linked to a small subset of...

2010-03-05 06:00:00

CARLSBAD, Calif., March 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that it has initiated a Phase 1 study of ISIS-SOD1Rx in patients with an inherited, aggressive form of Lou Gehrig's disease also known as familial amyotrophic lateral sclerosis (ALS). Approximately 20 percent of all familial ALS cases are caused by a mutant form of superoxide dismutase, or SOD1. ISIS-SOD1Rx is an antisense drug designed to inhibit the production of SOD1. The...

2009-10-20 15:11:49

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease that causes progressive weakness, disability, and death. Treatments are largely palliative. Using mice carrying the mutated form of the human SOD1 gene that causes inherited forms of ALS, however, Berislav Zlokovic and colleagues, at the University of Rochester Medical Center, Rochester, have now found that administration of the protein APC slows disease progression and extends survival....

2009-10-20 14:59:21

A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, in mice. The results offer a bit of good news in efforts to develop a therapy to stop or slow the progression of a disease that generally kills its victims within just a few years. In a paper published online Oct. 19 in the Journal of Clinical Investigation, scientists studied the use of a form of an enzyme known as...

2009-10-12 15:54:27

A new mouse model of amyotrophic lateral sclerosis (ALS) closely resembles humans with the paralyzing disorder, researchers at Washington University School of Medicine in St. Louis report. Like humans with ALS, the new genetically engineered mouse develops progressive paralysis; loses muscle mass and specific types of motor neurons, which are nerve cells that control muscles; and dies of the disorder, which is currently fatal in humans. "As far as we know, this is the first mouse model that...

2009-05-27 11:39:02

Researchers at the University of Texas have identified an abnormality in molecules they believe is responsible for one form of Lou Gehrig's disease. The molecules, known as immature superoxide dismutase 1 or SOD1, can't interact normally with metals that provide stability and instead become destructive knots that are seen in one inherited form of amyotrophic lateral sclerosis, the formal name of Lou Gehrig's disease, the University of Texas Health Science Center at San Antonio reports. The...

2009-03-03 10:30:00

An international consortium of scientists supported by the ALS Association has identified a new gene that may be responsible for about five percent of all inherited cases of amyotrophic lateral sclerosis (ALS), a progressive disease affecting nerve cells in the brain and spinal cord. Often called Lou Gehrig's disease, the condition is generally fatal within two to five years of diagnosis. The new gene, which has been dubbed ALS6, joins several other genes identified over the past few years....

2009-01-22 09:30:00

Discovery could help identify therapy for humans and dogsAn incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs. Researchers from the University of Missouri and the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic lateral sclerosis (ALS), the human disease also known as Lou Gehrig's Disease. As a result of the discovery, which will be published in...

2005-08-14 16:00:17

Bethesda, MD "“ A new study indicates that mutant Cu/Zn superoxide dismutase (SOD1) enzymes that are associated with an inherited form of Lou Gehrig's disease cause the protein to become sticky in tissues. Partial unfolding of the mutant protein can expose hydrophobic residues that may promote abnormal interactions with other proteins or membranes in the cell. The research appears as the "Paper of the Week" in the August 19 issue of the Journal of Biological Chemistry, an American...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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