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Latest Solubility Stories

2012-05-08 23:59:27

A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble. It also offers an opportunity to improve successful drugs that could be made even better with better solubility. The team's innovative findings were recently published in a study in...

2012-03-12 20:02:54

Peritectic solidification involves the nucleation and growth of the primary phase, the peritectic reaction of the primary phase with the remnant liquid phase, and the microstructural evolution of the product peritectic phase. It provides an effective approach for the synthesis or processing of various kinds of advanced materials. Professor WEI Bingbo and his group from the Department of Applied Physics, Northwestern Polytechnical University (NPU), in Xi'an, China, have demonstrated novel dual...

2011-07-19 15:24:32

Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area presents 2011 MAK and BAT values list with 82 modifications and new entries The 2011 MAK and BAT Values List compiled by the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, a Senate Commission of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), recommends reducing the general threshold limit value for dust for the alveolar fraction...

2011-06-28 20:32:13

Biocides turn out to be less toxic for the environment if they are subjected to microencapsulation, due to the fact that this process forms shell(s) for the substance. This is the conclusion of chemist Ms Mariluz Alonso in a thesis defended at the University of the Basque Country (UPV/EHU). In this research, she chose a number of biocides and other complementary substances, seeking a micro-encapsulation which, besides being compatible with the environment, is more soluble in water, more...

2011-04-07 05:00:00

BEND, Ore., April 7, 2011 /PRNewswire/ -- Bend Research Inc. (www.bendres.com), a leading independent drug-formulation development and manufacturing company, announced that it has received a new U.S. patent covering the use of polymer additives to improve and sustain the bioavailability of low-solubility drugs in the human body. The patent protects formulations that enhance the absorption of low-solubility drugs by blending the drug with an additive, resulting in improved...

2011-03-25 00:00:31

Low solubility is a common but complex hurdle on the path to phase I trials and commercialization. Typically, companies will have their compounds screened by a succession of separate vendors who are limited to their proprietary technology. This one at a time approach is often costly and time consuming. Research Triangle Park, NC (Vocus/PRWEB) March 24, 2011 Patheon (TSX: PTI), a leading provider of contract development and manufacturing services to the global pharmaceutical industry...

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2011-03-09 11:50:41

Graphene oxide has had a scrum of researchers fall upon it as it retains much of the properties of the highly valued super material pure graphene, but it is much easier, and cheaper, to make in bulk quantities; easier to process; and its significant oxygen content appears to make it soluble in water. However new research led by University of Warwick Chemist Dr Jonathan P. Rourke and University of Warwick Physicist Dr Neil Wilson, has found that that last assumption is incorrect and...

2010-09-22 09:00:00

BOULDER, Colo., Sept. 22 /PRNewswire/ -- Krill oil manufacturer Azantis Inc. and solubilization specialist Ceutical Switzerland AG announce the launch of water soluble krill oil. The omega-3 rich liquid krill oil, including the krill phospholipids, is now made available in a water solution for mixing and blending with other water based supplements, foods and drinks. Possible blend products are acai, noni, and other health juices and vitamin waters. The water soluble liquid krill oil is...

2010-07-28 13:16:15

Drug delivery inside the body is a complicated process. Compounds travel through a maze of aqueous solutions, lipid membranes, and barriers between the blood and tissues like the brain. Research reported in the American Institute of Physics publication the Journal of Chemical Physics presents a theoretical model that accurately predicts the hydration free energy (HFE) of a wide variety of organic compounds. "HFE determines solubility and allows accurate prediction of a compound's path in a...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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