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Latest Somatic evolution in cancer Stories

2014-07-11 10:56:11

Massachusetts General Hospital Circulating tumor cells captured with a microchip-based device developed at the Massachusetts General Hospital (MGH) Center for Engineering in Medicine and the MGH Cancer Center can be cultured to establish cell lines for genetic analysis and drug testing. In the July 11 issue of Science, an MGH research team reports that the cultured cells accurately reflect a tumor's genetic mutation over time and changing susceptibility to therapeutic drugs. "We now...

2014-04-11 12:07:26

A group of researchers in China and the US have successfully created a 3D model of a cancerous tumor using a 3D printer. The model, which consists of a scaffold of fibrous proteins coated in cervical cancer cells, has provided a realistic 3D representation of a tumor's environment and could help in the discovery of new drugs and cast new light on how tumors develop, grow and spread throughout the body. The results of the study have been published today, 11 April, in IOP Publishing's...

2014-04-10 14:53:02

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes. In the remaining 90% of cases are believed to have an increased risk of developing cancer in relation to genetic variants less powerful but more often, for example, doubles the risk of having a tumor that lacks this small...

2014-04-07 16:10:23

A blood sample could one day be enough to diagnose many types of solid cancers, or to monitor the amount of cancer in a patient's body and responses to treatment. Previous versions of the approach, which relies on monitoring levels of tumor DNA circulating in the blood, have required cumbersome and time-consuming steps to customize it to each patient or have not been sufficiently sensitive. Now, researchers at the Stanford University School of Medicine have devised a way to quickly bring...

2014-03-26 16:11:46

A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (UPCI). The finding warrants research into adding drugs that could prevent the cancer from hijacking patients' repressive gene...

2014-01-30 23:03:55

In the second whole-genome sequencing study ever conducted in bladder cancer, a Roswell Park-led team observed two distinct patterns of aberrations, and identified a potential target for therapy. Buffalo, NY (PRWEB) January 30, 2014 In the first whole-genome analysis conducted through the Roswell Park Cancer Institute (RPCI) Center for Personalized Medicine, researchers report that invasive bladder cancers demonstrate two distinct patterns of genetic alteration, one of which may result...

2014-01-24 13:27:45

Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient's tumor is likely to behave and which of several possible treatments is most likely to be effective. Reporting in the journal Cell Reports, researchers combined several types of data from pre- and post-treatment biopsies of breast tumors to obtain a molecular picture of how the cancer evolved as a result of chemotherapy. "Better understanding of tumor evolution is key to improving the...

2013-10-15 13:09:14

Computer scientists worked with doctors to develop new treatment that would kill cancer cells but spare healthy cells Researchers from the University of Minnesota, Mayo Clinic, and University of Toronto have successfully shown that a new method for targeting mutated cells could create a major breakthrough in a personalized medicine approach to treat cancer. The team’s findings are published in the Oct. 15 issue of Cancer Research, a journal of the American Association of Cancer...

2013-10-14 11:21:22

The study's authors identify new genetic pathways and new genes involved in bladder cancer; The genetic signature of these patients is a first step towards understanding the biology of this illness and improving patient management Bladder cancer represents a serious public health problem in many countries, especially in Spain, where 11,200 new cases are recorded every year, one of the highest rates in the world. The majority of these tumors have a good prognosis -- 70-80% five-year...

2013-09-24 09:44:43

USC microbiologists describe how 'natural killer' cells depend on enzyme to develop Natural killer (NK) cells in the human body can kill and contain viruses and cancerous tumors, and a new study from the University of Southern California (USC) describes for the first time how those cells can be manipulated by epigenetics. The discovery, detailed in the Proceedings of the National Academy of Sciences, paves the way for developing more effective cancer drugs. "Natural killer cells are...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.