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Latest SOX2 Stories

Nuanced Approach To Creating Stem Cells
2013-07-19 10:25:21

Brett Smith for redOrbit.com - Your Universe Online Stem cell studies are producing some of the most promising research results for replacing or regenerating damaged tissue, and a new study from a team of Spanish and American scientists has described a more flexible approach to creating the valuable cells. Nobel Prize laureate Shinya Yamanaka developed the initial formula for developing induced pluripotent stem cells (iPSCs), or stem cells created by reverse-engineering...

2013-06-03 23:17:40

Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier genes can replace OCT4 and SOX2, the core regulators of cell pluripotency. The results were published in the May 23rd issue of Cell, titled “Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers”. Rockville, MD (PRWEB) June 03, 2013 Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier...

New Efficiency Brought To Stem Cell Reprogramming
2012-09-13 12:35:17

Biologists reveal genes key to development of pluripotency, in single cells Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells – cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic...

2012-03-14 20:46:55

Researchers at the RIKEN Omics Science Center (OSC) have successfully developed and demonstrated a new experimental technique for producing cells with specific functions through the artificial reconstruction of transcriptional regulatory networks. As an alternative to induced pluripotent stem cells, the technique promises to enable faster and more efficient production of functional cells for use in cancer therapy and a variety of other areas. Starting with the first-ever production of...

2011-10-06 13:15:15

Mass. General/Harvard study shows Sox2 expression is a widespread marker of adult stem cells Investigators at the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HSCI) have found that Sox2 — one of the transcription factors used in the conversion of adult stem cells into induced pluripotent stem cells (iPSCs) — is expressed in many adult tissues where it had not been previously observed. They also confirmed that...

2011-05-18 13:40:48

A team of scientists from Genome Institute of Singapore (GIS) of the Agency for Science, Technology and Research (A*STAR) have shown how proteins involved in controlling genes work together to carry out their functions in stem cells and demonstrated for the very first time, how they can change interaction partners to make other types of cells. The work highlighted the collaborative nature of modern biology in which techniques and knowledge from bioinformatics analysis, structural biology,...

2011-04-28 14:38:17

Like people with a big choice to make, stem cells have a process to "decide" whether to transform into a specific cell type or to stay flexible, a state that biologists call "pluripotency." Using a technology he invented, Brown researcher William Fairbrother and colleagues have discovered new molecular interactions in the process that will help regenerative medicine researchers better understand pluripotency. In a paper published in advance online in the journal Genome Research, Fairbrother's...

2010-04-15 14:29:34

A new technique for reprogramming human adult cells could greatly improve the safety and efficiency of producing patient-specific stem cells for use in a range of therapeutic applications to repair or replace damaged or diseased tissues. A description of this innovative strategy is published in the peer-reviewed journal Cellular Reprogramming, published by Mary Ann Liebert, Inc. The paper is available free online. Stem cells offer great promise for use in cellular therapy to regenerate...

2010-01-21 17:19:22

Singapore scientists' surprising discovery potentially relevant to cell-therapy-based medicine In the new issue of the journal Cell Stem Cell, Singapore scientists report the surprising discovery that a novel transcription factor, Nr5a2, can replace one of the classical reprogramming factors, Oct 4, to significantly increase the efficiency of reprogramming differentiated stem cells into induced pluripotent stem cells (iPS cells). Previous research revealed that the reprogramming of...

2009-10-18 12:32:54

Development of 2-week method for generating human induced-pluripotent stem cells with 200-fold increase in yield Fate Therapeutics, Inc. announced today the generation of human induced-pluripotent stem cells (iPSCs) using a combination of small molecules that significantly improves the speed and efficiency of reprogramming. The discoveries, which were made by Sheng Ding, Ph.D. under a research collaboration between Fate Therapeutics and The Scripps Research Institute (TSRI), represent a more...