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2009-10-18 12:23:29

The findings by Scripps Research scientists brighten prospects of stem cell therapy for range of diseases A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine. The findings were published in an advance, online issue of...

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2009-08-09 12:35:00

A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become cancerous in their tracks but also controls somatic cell reprogramming.Although scientists have learned how to reprogram adult human cells such as skin cells into so-called induced pluripotent stem cells (iPSCs), the reprogramming efficiency is still woefully low. The Salk study,...

2009-07-29 14:10:44

Research Team at WPI and CellThera Discovers a Way toTurn on Stem Cell Genes in Human Skin Cells Without Using Viruses or Inserting New GenesThe research team reported its findings in the paper "Induction of Stem Cell Gene Expression in Adult Human Fibroblasts without Transgenes," published online July 21, 2009 (in advance of September print publication) as a "fast track" paper from the journal Cloning and Stem Cells. (Cloning, Stem Cells. 2009 Jul 21.)   "We show that by...

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2009-05-01 09:26:16

Researchers have discovered an added layer of complexity in the network that determines human embryonic stem cell fate. A report publishing online April 30th in the journal Cell, a Cell Press publication, shows that a microRNA known as miR-145 lowers the activity of three key ingredients in the "recipe" for making embryonic stem cells. The discovery may have implications for improving the efficiency of methods designed to reprogram differentiated cells into embryonic stem cell-like cells and...

2009-02-06 08:38:21

The simple recipe scientists earlier discovered for making adult stem cells behave like embryonic-like stem cells just got even simpler. A new report in the February 6th issue of the journal Cell, a Cell Press publication, shows for the first time that neural stem cells taken from adult mice can take on the characteristics of embryonic stem cells with the addition of a single transcription factor. Transcription factors are genes that control the activity of other genes.The discovery follows a...

2008-12-16 10:15:00

Whitehead Institute researchers have greatly simplified the creation of so-called induced pluripotent stem (iPS) cells, cutting the number of viruses used in the reprogramming process from four to one. Scientists hope that these embryonic stem-cell-like cells could eventually be used to treat such ailments as Parkinson's disease and diabetes.The earliest reprogramming efforts relied on four separate viruses to transfer genes into the cells' DNA--one virus for each reprogramming gene (Oct4,...

2008-11-06 18:00:06

U.S. scientists say they have identified compounds for stem cell production from adult cells, moving medicine closer to the reprogramming of general cells. Scripps Research Institute scientists said they screened known drugs and identified small molecules that could replace conventional reprogramming genes. They said the process they developed offers a new way to generate stem cells from fibroblasts, a general cell type that is abundant and easily accessible from various tissues, including...

2008-10-10 18:00:10

Tokyo, Oct. 10 (Jiji Press)--Shinya Yamanaka, a professor at Kyoto University, and his colleagues have created iPS cells from mice cells without using viral vectors that can cause cancer. Yamanaka's team is now trying to make similarly safe induced pluripotent stem cells from adult human cells. If the work proves successful, it should bring closer to reality the clinical application of iPS cells, such as treatments for spinal cord injuries and diabetes, medical experts said. Yamanaka...

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2008-09-26 09:00:00

Researchers claim they developed a safer way to make powerful stem cells from ordinary skin cells, improving research focused on so-called regenerative medicine.They used a common cold virus to carry transformative genes into ordinary mouse cells and made them look and act like embryonic stem cells.If it can be replicated with human cells, it may offer a safe way to test cell therapy to treat diseases such as sickle cell anemia or Parkinson's, Konrad Hochedlinger of Massachusetts General...

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2008-03-24 11:05:00

M. D. Anderson team connects REST to regenerative medicine, pediatric brain cancerA protein known as REST blocks the expression of a microRNA that prevents embryonic stem cells from reproducing themselves and causes them to differentiate into specific cell types, scientists at The University of Texas M. D. Anderson Cancer Center report in the journal Nature. Researchers show RE1-silencing transcription factor (REST) plays a dual role in embryonic stem cells, said senior author Sadhan...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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