Latest Spanish National Cancer Research Centre Stories
A study led by Oscar Fernandez-Capetillo has deciphered the components of the machinery that duplicates DNA, the replisome, on which most chemotherapeutic agents currently act The Genomic Instability Group led by researcher Óscar Fernández-Capetillo at the Spanish National Cancer Research Centre (CNIO), has for the first time obtained a panoramic photo of the proteins that take part in human DNA division, a process known as replication. The research article, published today in the...
A research project led by CNIO scientists clarifies how tissues and organs select the 'best' cells for themselves, at the expense of 'losers' who might cause disease Scientists from the Spanish National Cancer Research Centre (CNIO) describe how natural selection also occurs at the cellular level, and how our body's tissues and organs strive to retain the best cells in their ranks in order to fend off disease processes. These results appear this week in the new issue of Cell Reports. The...
This approach is described in the work published today in the Journal of Clinical Investigation, which sheds light on the mechanisms that regulate squamous cell carcinoma development Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult...
Alfonso Valencia's group discover proteins made by combining different genes in healthy cells and tissues To date this has been considered a rarity confined to anomalous processes like cancer The authors believe their finding opens a new line of research inquiry with multiple implications in Human Genomics and cancer Sequencing the human genome was just the first step. The next challenge is of the kind that makes history: to decode the genome, and understand how the information...
The study has demonstrated that genetic variability in the embryo may predispose to cancer in adult life A study recently published in Nature Genetics provides new evidence that the genetic makeup of the embryo may cause the appearance of tumors in adult life. These results bear out the growing theory that some tumors may have an extremely early origin, tracing to the individual's embryonic development, while offering new clues to understand the genetic causes of certain kinds of cancer,...
Mouse lifespan extended up to 24 percent with a single treatment A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes permanently from the embryonic stage – an approach impracticable in humans. Researchers at the Spanish National Cancer Research Centre (CNIO), led by its director María Blasco, have proved that mouse...
They have identified new functions of cohesin SA1 that are relevant for cancer and CdLS Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their functional specificity has been largely ignored. Researchers of the Spanish National Cancer Research Centre (CNIO) under the direction of Ana Losada have identified new functions of...
