Latest Spermatogenesis Stories

Treatments for childhood cancers are increasingly successful with cure rates approaching 80%, but success often comes with a downside for the surviving men: the cancer treatments they received as boys can leave them sterile as adults. Now, a research team led by Ralph Brinster of the University of Pennsylvania School of Veterinary Medicine has completed a 14-year experiment that gives hope for a technique that could restore their fertility.  Brinster is the Richard King Mellon Professor...

A Ben-Gurion University of the Negev researcher has achieved a significant breakthrough in male fertility, producing normal sperm from mouse cells. "This study may open new therapeutic strategies for infertile men who cannot generate sperm and/or pre-pubertal cancer patients at risk of infertility due to aggressive chemo- or radiotherapy and cannot cryopreserve sperm as in adult patients," explains Prof. Mahmoud Huleihel, of BGU's Shraga Segal Department of Microbiology and Immunology in...

Reproductive researchers from the University of Pennsylvania and The Children's Hospital of Philadelphia have succeeded in isolating and transplanting pure populations of the immature cells that enable male reproduction in two species"”human spermatogonia and mouse gonocytes. These germline stem cells, taken from testis biopsies, demonstrated viability following transplantation to mouse testes within a controlled laboratory setting.The results indicate remarkable similarity between the gene...

Findings may lead to development of novel approach for male contraceptionVirginia Commonwealth University School of Medicine researchers have discovered a gene involved with the production of sperm that may contribute to male infertility and lead to new approaches to male contraception.One in six couples trying to conceive a baby is affected by infertility, according to the American Fertility Association "“ and in about half of these cases, a male factor is present. Sperm defects are often...