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Latest Spindle apparatus Stories

2011-09-08 20:54:30

Researchers at the California Institute of Technology (Caltech) have obtained the first high-resolution, three-dimensional images of a cell with a nucleus undergoing cell division. The observations, made using a powerful imaging technique in combination with a new method for slicing cell samples, indicate that one of the characteristic steps of mitosis is significantly different in some cells. During mitosis, two sets of chromosomes get paired up at the center of the cell's nucleus. Then...

2011-08-29 12:07:09

Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes far-off the center in preparation for the highly asymmetric cell division that completes oocyte maturation upon fertilization of the egg, report researchers at the Stowers Institute for Medical Research. Their findings illustrate how oocytes repurposed a dynamic cellular mechanism capable of generating considerable...

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2011-08-18 13:48:11

When an egg cell is being formed, the cellular machinery which separates chromosomes is extremely imprecise at fishing them out of the cell's interior, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. The unexpected degree of trial-and-error involved in this process could explain why errors in the number of chromosomes in the egg cell are the leading cause of miscarriages and severe congenital diseases such as trisomies like Down's...

2011-04-14 21:03:08

Egg cells failing to properly arrange chromosomes Washington State University researchers have confirmed a critical step in cell division that results in age-related miscarriages and birth defects, including Down syndrome. Writing in the upcoming issue of the journal "Current Biology," the researchers say they recreated the conditions in which an egg cell will continue to undergo cell division without properly arranging its chromosomes, creating offspring with aneuploidy, or an abnormal...

2011-04-05 00:05:23

Discovery points to a potential co-contributor to cilia-related diseases Researchers at the University of Massachusetts Medical School have described a previously unknown role for the cilia protein IFT88 in mitosis, the process by which a dividing cell separates its chromosomes containing the cell's DNA into two identical sets of new daughter cells. Published in advance online by Nature Cell Biology, this newly discovered function for IFT88 suggests a possible alternative or contributory...

2010-11-25 22:08:47

Accurate gene distribution during cell division depends on stable set-up Scientists have discovered an amazingly simple way that cells stabilize their machinery for forcing apart chromosomes. Their findings are reported Nov. 25 in Nature. When a cell gets ready to split into new cells, this stable set-up permits its genetic material to be separated and distributed accurately. Otherwise, problem cells "“ like cancer cells"” arise. The human body contains more than a trillion cells,...

2010-11-17 17:08:28

Teams from UK and Germany publish research in Nature Cell Biology New research that provides potential for exciting new approaches to targeting diseases such as cancer has been announced by an international team of academics. They have also announced the potential for more targeted treatments following their identification of proteins that play a vital role in the life of a human cell. The research teams from Germany and the UK have published their work in the Advance Online Publication on...

2010-11-07 10:49:50

Potentially big implications for cancer control By tracking the flow of information in a cell preparing to split, Johns Hopkins scientists have identified a protein mechanism that coordinates and regulates the dynamics of shape change necessary for division of a single cell into two daughter cells. The protein, called 14-3-3, sits at an intersection where it integrates converging signals from within the cell and cues cell shape change and, ultimately, the splitting that allows for normal and...

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2010-10-15 08:16:31

Unless you are in a field of study related to cell biology, you most likely have never heard of Ndc80. Yet this protein complex is essential to mitosis, the process by which a living cell separates its chromosomes and distributes them equally between its two daughter cells. Now, through a combination of cryo-electron microscopy and three-dimensional image reconstruction, a team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC)...

2010-09-17 14:00:05

On average, one hundred billion cells in the human body divide over the course of a day. Most of the time the body gets it right but sometimes, problems in cell replication can lead to abnormalities in chromosomes resulting in many types of disorders, from cancer to Down Syndrome. Now, researchers at the University of Pennsylvania's School of Medicine have defined the structure of a key molecule that plays a central role in how DNA is duplicated and then moved correctly and equally into two...


Latest Spindle apparatus Reference Libraries

Arbacia punctulata
2013-11-06 11:08:03

Arbacia punctulata is a species of Arbacia genus of purple-spined sea urchins. Its natural habitat is in the Western Atlantic Ocean. It can be found in shallow water from Massachusetts to Cuba and the Yucatan Peninsula, from Texas to Florida in the Gulf of Mexico, the coast from Panama to French Guiana and in the Lesser Antilles, normally on sandy, rocky, or shelly bottoms. It is omnivorous, consuming a wide variety of preys. It’s been shown that it is galactolipids, rather than...

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Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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