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Last updated on April 18, 2014 at 17:24 EDT

Latest Spliceosome Stories

2014-04-07 16:03:04

Some three billion base pairs make up the human genome—the floor plan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights relevant to human health and disease. Nevertheless, the primary actors in virtually all life processes are the proteins coded for by DNA sequences known as genes. For a broad spectrum of diseases, proteins can yield far more compelling revelations than may be gleaned...

2014-02-05 23:03:02

A study led by St. Jude Children’s Research Hospital offers a new avenue for scientists to pursue in the quest for desperately needed treatments for ALS Memphis, Tenn. (PRWEB) February 05, 2014 St. Jude Children’s Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis (ALS) disrupt the RNA transport system in nerve cells. The findings appear in the current issue of the scientific journal Neuron and offer a new focus for...

Two Human Proteins Found To Affect How 'Jumping Gene' Gets Around
2013-11-21 13:55:24

Johns Hopkins Medicine Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the Nov. 21 issue of Cell, breaks new ground, they say, in understanding the arms race between a jumping gene driven to colonize new areas of the human genome and cells working to limit the risk posed by such volatile bits of DNA. Jumping genes, more...

2013-11-11 11:09:02

A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression. The study was published on line in advance of print November 10 in the journal Nature Structural and Molecular Biology. "We uncovered a novel mechanism that allows proteins that direct pre-mRNA splicing – RNA-binding proteins – to induce a regulatory effect from greater distances than was thought possible,"...

Faulty Enzymes Cause Diabetic Cardiomyopathy
2013-11-07 09:18:20

redOrbit Staff & Wire Reports - Your Universe Online A family of enzymes that controls the functions of other proteins could be the possible cause of heart failure in diabetics, according to new research appearing in the Journal of Biological Chemistry. While many studies have been written on cardiovascular disease and diabetes, little is known about diabetic cardiomyopathy, a disorder of the heart muscle in diabetes patients that can lead to the heart’s inability to effectively...

Unraveling Secrets Of The Mechanism That Snips Our Genes
2013-09-27 09:50:05

Brandeis University Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing. These conditions are difficult to prevent because scientists are still grasping to understand how the splicing process works. Now, researchers from Brandeis University and the University of Massachusetts Medical School have teamed up to unravel...

2013-06-24 14:45:26

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today. Roughly 3 meters of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others. Dr Tim Mercer and Professor John...

Shining Light On Important Role Performed By Dark Matter Within Each Of Our Genes
2013-01-07 09:28:56

University of North Carolina Health Care Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or "junk DNA," within each of our genes. The new study reveals snippets of information contained in dark matter that can alter the way a gene is assembled. "These small sequences of genetic information tell the gene how to splice, either by enhancing the splicing process or...

2012-09-10 14:24:17

$100,000 prize honors female scientists who have made extraordinary contributions to biomedical science NEW YORK, Sept. 10, 2012 /PRNewswire-USNewswire/ -- Joan A. Steitz, Ph.D., a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases, will be awarded the 2012 Pearl Meister Greengard Prize from The Rockefeller University. The prize, which honors female scientists who have made extraordinary contributions to biomedical science and...

2012-08-15 11:57:20

Targeted 'negative ASOs' cause missplicing and pathogenesis, providing unique window on disease progression A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases — those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders...