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Latest Spliceosome Stories

2014-08-07 16:27:47

-Results published in Science show small molecule SMN2 splicing modifiers to be effective in SMA mouse models- SOUTH PLAINFIELD, N.J., Aug. 7, 2014 /PRNewswire/ -- Today the journal Science published results of a preclinical study demonstrating that treatment with orally available RNA splicing modifiers of the SMN2 gene starting early after birth is preventing deficits in mouse models of Spinal Muscular Atrophy (SMA). Scientists from Roche Pharma Research and Early Development...

2014-06-17 16:25:38

Messenger RNA Therapeutics(TM) leader joins short list of major innovators for potential to transform the treatment of many diseases CAMBRIDGE, Mass., June 17, 2014 /PRNewswire/ -- Moderna Therapeutics, the pioneer in developing messenger RNA (mRNA) Therapeutics(TM), today announced it was named to the 2014 CNBC Disruptor 50 list. CNBC recognizes Moderna as one of the top 50 companies whose innovations are having a dramatic impact across their industries, and are poised for hyper-growth....

2014-04-22 10:47:36

Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function of the heart. Using mouse models, researchers at Baylor College of Medicine have now been able to categorize the alternative splicing (the process in which genes code proteins, determining their role) that takes place during these changes and what mechanisms they affect. The findings, which appear in...

2014-04-07 16:03:04

Some three billion base pairs make up the human genome—the floor plan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights relevant to human health and disease. Nevertheless, the primary actors in virtually all life processes are the proteins coded for by DNA sequences known as genes. For a broad spectrum of diseases, proteins can yield far more compelling revelations than may be gleaned...

2014-02-05 23:03:02

A study led by St. Jude Children’s Research Hospital offers a new avenue for scientists to pursue in the quest for desperately needed treatments for ALS Memphis, Tenn. (PRWEB) February 05, 2014 St. Jude Children’s Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis (ALS) disrupt the RNA transport system in nerve cells. The findings appear in the current issue of the scientific journal Neuron and offer a new focus for...

Two Human Proteins Found To Affect How 'Jumping Gene' Gets Around
2013-11-21 13:55:24

Johns Hopkins Medicine Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the Nov. 21 issue of Cell, breaks new ground, they say, in understanding the arms race between a jumping gene driven to colonize new areas of the human genome and cells working to limit the risk posed by such volatile bits of DNA. Jumping genes, more...

2013-11-11 11:09:02

A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression. The study was published on line in advance of print November 10 in the journal Nature Structural and Molecular Biology. "We uncovered a novel mechanism that allows proteins that direct pre-mRNA splicing – RNA-binding proteins – to induce a regulatory effect from greater distances than was thought possible,"...

Faulty Enzymes Cause Diabetic Cardiomyopathy
2013-11-07 09:18:20

redOrbit Staff & Wire Reports - Your Universe Online A family of enzymes that controls the functions of other proteins could be the possible cause of heart failure in diabetics, according to new research appearing in the Journal of Biological Chemistry. While many studies have been written on cardiovascular disease and diabetes, little is known about diabetic cardiomyopathy, a disorder of the heart muscle in diabetes patients that can lead to the heart’s inability to effectively...

Unraveling Secrets Of The Mechanism That Snips Our Genes
2013-09-27 09:50:05

Brandeis University Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing. These conditions are difficult to prevent because scientists are still grasping to understand how the splicing process works. Now, researchers from Brandeis University and the University of Massachusetts Medical School have teamed up to unravel...

2013-06-24 14:45:26

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today. Roughly 3 meters of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others. Dr Tim Mercer and Professor John...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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