Latest Sterol regulatory element binding protein Stories

2009-11-18 13:51:04

May Promote Prion-Dependent Diseases The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells. With these findings, published in the current issue of the Journal of Biological Chemistry, scientists of Helmholtz Zentrum Mnchen and Technische Universität Mnchen anticipate new approaches in drug development to combat prion infection. Prions are causing fatal and infectious diseases of the nervous system, such as...

2009-09-11 08:25:38

Research by UC Riverside scientists is first to link passive smoking to nonalcoholic fatty liver disease A team of scientists at the University of California, Riverside has found that even second-hand tobacco smoke exposure can result in nonalcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury in which fat accumulates in the liver of people who drink little or no alcohol. The researchers found fat accumulated in liver cells of mice exposed to...

2009-08-31 08:11:54

A small molecule earlier found to have both anti-fat and anti-cancer properties is a literal turnoff for fat-making genes, according to a new report. The chemical, which the researchers call fatostatin, blocks a well known master controller of fat synthesis, a transcription factor known as SREBP. That action in mice that are genetically prone to obesity causes the animals to become leaner. It lowers the amount of fat in their livers, as well as their blood sugar and cholesterol levels. "We...

2005-08-11 19:05:00

72 years ago, the first evidence for end-product feedback regulation of a biosynthetic pathway was demonstrated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol. In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liver sense cholesterol and thus regulate cholesterol production remained unknown....

2005-06-07 18:43:45

(Uppsala, June 7th) - A team of investigators from the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR) and Harvard Medical School has uncovered novel targets for the development of drugs that would potentially complement, or replace, statins in treating heart disease. Statins are commonly taken drugs that reduce the levels of low density lipoprotein (LDL) and have been shown to reduce risks associated with heart disease, the number one killer in the Western world. However,...

Word of the Day
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'