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Latest STK11 Stories

Study Reveals Protein That Keeps People And Their Skeletons Organized
2013-11-14 10:34:42

University of Southern California Most people think that their planners or their iPhones keep them organized, when proteins such as liver kinase b1 (Lkb1) actually have a lot more to do with it. New research from postdoctoral fellow Lick Lai in the lab of USC scientist Andy McMahon published in Proceedings of the National Academy of Sciences (PNAS) sheds light on how this important protein keeps people organized on a basic level by promoting orderly skeletal growth and preventing skeletal...

2013-10-03 09:06:40

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered some key features that explain just what turns on a protein that is considered to be a master regulator of how the human body uses and stores energy. The new discoveries could help in the design and development of new therapeutics to treat metabolic disease such as diabetes and obesity—and perhaps some cancers as well. The new study, led by Patrick R. Griffin, chair of the TSRI Department of...

Diabetes Drug Holds Promise As Lung Cancer Cure
2013-01-30 11:03:59

Watch the video "Diabetes Drug Could Hold Promise For Lung Cancer Patients" Brett Smith for redOrbit.com - Your Universe Online Scientists have been enthusiastic about the potential use of widely available diabetes drugs to treat various types of cancer. A new study from The Salk Institute for Biological Studies and the David Geffen UCLA School of Medicine suggests that these metabolism-affecting drugs can decrease the size of lung tumors in mice and increase their chances for...

Protein Assists The Spread Of Breast Cancer
2012-01-18 06:02:54

Researchers have uncovered a protein that helps some breast cancer tumors to break through their surrounding cell matrix and spread to other tissues. The protein, called hepsin, is a protease which is a class of enzymes that cuts other proteins. Proteases can be successfully targeted by drugs, providing the opportunity to target hepsin as a possible new treatment. Co-author Zena Werb, PhD, a professor of anatomy at University of California - San Francisco, said “If we could delay...

2010-12-01 22:49:16

University of Michigan researchers have discovered that a protein known to regulate cellular metabolism is also necessary for normal cell division in blood-forming stem cells. Loss of the protein results in an abnormal number of chromosomes and a high rate of cell death. The finding demonstrates that stem cells are metabolically different from other blood-forming cells, which can divide without the protein, Lkb1. This metabolic difference could someday be used to better control the behavior...

2010-06-15 00:55:36

A new study uses a sophisticated genomic analysis to unravel some of the complex cellular signals that drive the deadly invasive spread of lung cancer. The research, published by Cell Press in the June issue of the journal Cancer Cell, identifies specific molecules involved in the often fatal metastasis of a common type of non-small cell lung cancer (NSCLC) and uses this information to design effective therapeutic strategies. "Previous cancer genomics studies have established a number of...

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2009-06-15 16:30:00

Tumor metabolism discovery opens new detection and treatment possibilities for rare form of colon cancerPeople who suffer from Peutz-Jeghers syndrome, a rare inherited cancer syndrome, develop gastrointestinal polyps and are predisposed to colon cancer and other tumor types. Carefully tracing the cellular chain-of-command that links nutrient intake to cell growth (and which is interrupted in Peutz-Jeghers syndrome), allowed researchers at the Salk Institute for Biological Studies to exploit...

2009-01-30 09:13:55

Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell, may direct new therapeutic strategies for multiple types of cancer.The protein kinase LKB1 is a known tumor suppressor and the LKB1-AMPK signaling pathway couples energy metabolism with cell growth, proliferation and survival. "Mutations in LKB1 are not...

2005-08-19 14:37:34

HANOVER, NH "“ In an ongoing effort to fight disease by manipulating energy regulation of cells, a collaborative study led by Dartmouth Medical School (DMS) has demonstrated that cells lacking a tumor-suppressing kinase called LKB1 can still maintain healthy energy levels when they become stressed. This energy regulation is essential for keeping cells from dying off too quickly. The study's results could signal new advances for combating cancerous tumor growth, but also type 2 diabetes...