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Latest Structure and genome of HIV Stories

2010-07-15 15:11:21

How a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought, according to Penn State College of Medicine researchers. Understanding the steps a virus takes for assembly could allow development of a way to prevent the spread of retroviral diseases. The team studied a chicken virus called Rous sarcoma virus that causes cancer in chickens and is similar to HIV. "The question is, how do retroviruses build new virus particles?" asked Leslie Parent, M.D.,...

2010-06-23 01:21:31

The UK's National Physical Laboratory (NPL) is involved in a collaborative project that is helping to further the understanding of HIV viral protein structure which could lead to new molecular medicines. In May 2010 the project team, comprising biotechnology experts from NPL, the University of Edinburgh and IBM T.J. Watson Research Center, published some of their research in Journal of Physical Chemistry B. The article sets out to resolve controversy over how part of an HIV protein is...

2009-12-15 23:43:33

Human Erythrocytes Selectively Bind and Enrich Infectious HIV-1 Virions Free infectious HIV-1 is widely thought to be the major form of the virus in the blood of infected persons. U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors. The results were published on today in PLoS ONE, and can be accessed here....

2009-11-12 12:36:40

Structural biologists at the University of Pittsburgh School of Medicine have described the architecture of the complex of protein units that make up the coat surrounding the HIV genome and identified in it a "seam" of functional importance that previously went unrecognized. Those findings, reported today in Cell, could point the way to new treatments for blocking HIV infection. The researchers used a combination of nuclear magnetic resonance and cryoEM, which are standard structural biology...

2009-06-25 11:27:32

Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular...

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2009-06-23 10:45:00

Scientists at the European Molecular Biology Laboratory (EMBL) and the University Clinic Heidelberg, Germany, have produced a three-dimensional reconstruction of HIV (Human Immunodeficiency Virus), which shows the structure of the immature form of the virus at unprecedented detail. Immature HIV is a precursor of the infectious virus, which can cause AIDS. The study, published in the 22-26 June online edition of PNAS, describes how the protein coat that packages the virus' genetic material...

2009-06-10 14:33:16

Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal's Jewish General Hospital "“ along with colleagues at the University of Manitoba and the University of British Columbia "“ may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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