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Last updated on April 16, 2014 at 1:21 EDT

Latest Suprachiasmatic nucleus Stories

2014-03-28 09:23:18

You've switched to the night shift and your weight skyrockets, or you wake at 7 a.m. on weekdays but sleep until noon on weekends—a social jet lag that can fog your Saturday and Sunday. Life runs on rhythms driven by circadian clocks, and disruption of these cycles is associated with serious physical and emotional problems, says Orie Shafer, a University of Michigan assistant professor of molecular, cellular and developmental biology. Now, new findings from Shafer and U-M doctoral...

VIP Treatment For Jet Lag
2013-10-28 16:18:42

Washington University in St. Louis A brain chemical that desynchronizes the cells in the biological clock helps the clock adjust more quickly to abrupt shifts in daily light/dark schedules such as those that plague modern life A small molecule called VIP, known to synchronize time-keeping neurons in the brain's biological clock, has the startling effect of desynchronizing them at higher dosages, says a research team at Washington University in St. Louis. Far from being catastrophic,...

2013-10-16 16:26:29

WASHINGTON, Oct. 16, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (VANDA) (NASDAQ: VNDA) today announced that the U.S. Food and Drug Administration (FDA) has notified the company of the scheduling of a Peripheral and Central Nervous System Drugs Advisory Committee meeting on November 14, 2013, for the review of Vanda's New Drug Application (NDA) for tasimelteon, proposed trade name HETLIOZ(TM), for the treatment of Non-24-Hour Disorder (Non-24) in the totally blind. Vanda's...

2013-07-29 20:21:11

WASHINGTON, July 29, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (VANDA) (NASDAQ: VNDA) today announced that the U.S. Food and Drug Administration (FDA) has accepted the filing and granted a priority review classification to Vanda's New Drug Application (NDA) for tasimelteon, a circadian regulator for the treatment of Non-24-Hour Disorder (Non-24) in the totally blind. The FDA grants priority review status for a "drug that treats a serious condition and, if approved, would...

2013-06-19 14:29:34

Gladstone-led study sheds light on molecular basis for metabolic health and disease Inside each of us is our own internal timing device. It drives everything from sleep cycles to metabolism, but the inner-workings of this so-called "circadian clock" are complex, and the molecular processes behind it have long eluded scientists. But now, researchers at the Gladstone Institutes have discovered how one important protein falls under direct instructions from the body's circadian clock....

2013-06-17 20:21:16

Data presented at ENDO 2013, the Endocrine Society's 95th Annual Meeting WASHINGTON, June 17, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA) presented additional data today at ENDO 2013, the Endocrine Society's 95(th) Annual Meeting, demonstrating that tasimelteon can entrain (synchronize) both melatonin and cortisol rhythms. This effect further confirms tasimelteon's potential to reset the master body clock and address the circadian desynchrony which is...

2013-06-05 20:24:00

Data presented as a late breaking abstract at SLEEP 2013, the 27th Annual Meeting of Associated Professional Sleep Societies WASHINGTON, June 5, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA) presented additional entrainment and patient-level clinical data at SLEEP 2013, the 27th Annual Meeting of Associated Professional Sleep Societies in Baltimore, from its SET (Safety and Efficacy of Tasimelteon) and RESET (Randomized-withdrawal study of the Efficacy and...

2013-05-31 08:24:00

WASHINGTON, May 31, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (VANDA) (NASDAQ: VNDA) today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for tasimelteon, a circadian regulator. Vanda is seeking FDA approval of tasimelteon for the treatment of Non-24-Hour Disorder (Non-24) in the totally blind. Tasimelteon was developed to address a significant unmet medical need, the treatment of Non-24, for which there are currently no FDA...

2013-05-30 20:21:28

-- Data to be presented at SLEEP 2013 27th Annual Meeting of the Associated Professional Sleep Societies and the Endocrine Society's 95th Annual Meeting WASHINGTON, May 30, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (VANDA) (NASDAQ: VNDA) today announced that data from the Phase III studies of tasimelteon in Non-24-Hour Disorder (Non-24) will be presented at SLEEP 2013, the 27th Annual Meeting of the Associated Professional Sleep Societies, LLC being held from June 1, 2013...

Depression Can Alter A Person’s Circadian Clock At The Cellular Level
2013-05-14 07:16:55

redOrbit Staff & Wire Reports - Your Universe Online The circadian clock rhythms that help govern biological, hormonal and behavioral patterns in the human body are altered at the cellular level in people suffering from depression, according to new research published in the Proceedings of the National Academy of Sciences (PNAS). According to the researchers, every cell in the human body operates on a 24-hour clock, with the brain serving as the timekeeper that helps keep things...